Incidence and patterns of isolated brain failure in stage III non-small-cell lung cancer treated with concurrent chemoradiation therapy
| Autor: | Masaaki Kataoka, Yasushi Hamamoto, K. Uwatsu, Tadaaki Takahashi, Shinya Sakai, Takatoshi Senba, Shogo Oda, Shoji Aono, Takeshi Inoue, Yoshifumi Sugawara |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Oncology medicine.medical_specialty Lung Neoplasms Multiple Organ Failure medicine.medical_treatment Kaplan-Meier Estimate Text mining Carcinoma Non-Small-Cell Lung Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Radiology Nuclear Medicine and imaging Stage (cooking) Lung cancer Aged Neoplasm Staging Retrospective Studies Aged 80 and over Brain Diseases business.industry Incidence (epidemiology) Brain Concurrent chemoradiation Middle Aged Isolated brain medicine.disease Combined Modality Therapy respiratory tract diseases Stage III Non-Small Cell Lung Cancer Radiation therapy Female business Follow-Up Studies |
| Zdroj: | Japanese Journal of Radiology. 27:25-30 |
| ISSN: | 1867-108X 1867-1071 |
| DOI: | 10.1007/s11604-008-0292-1 |
| Popis: | The incidence and patterns of isolated brain failure was examined in patients with stage III non-small-cell lung cancer (NSCLC) treated with concurrent chemoradiation (CCRT).Between 1996 and 2003, a total of 68 patients with stage III NSCLC were treated with radical CCRT. Among them, 63 patients were evaluable. Radiation therapy with a mean total dose of 61.4 Gy and chemotherapy (typically platinum-based) were administered concurrently.Other than locoregional failure, isolated brain failure was the most common failure pattern as the initial failure, occurring 2-37 months (median 6.5 months) after radical CCRT. The isolated brain failure rates as the initial failure at 1, 3, and 4 years were 9%, 13%, and 25%, respectively. Isolated brain failure as the initial failure occurred more frequently in T4 cases (39% at 4 years) compared to T1-3 cases (14% at 4 years) in our series (P = 0.0099).Except for locoregional failure, isolated brain failure was the most common initial failure pattern of stage III NSCLCs treated with radical CCRT. Isolated brain failure as the initial failure occurred even after 3 years. Isolated brain failure as the initial failure occurred more frequently in T4 cases than in T1-3 cases. |
| Databáze: | OpenAIRE |
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