Osteoclast function and bone-resorbing activity: An overview
| Autor: | Neil Alles, Niroshani S. Soysa |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Bone remodeling period Integrins medicine.medical_specialty Podosome Bone disease Osteoporosis Biophysics Osteoclasts Biochemistry Bone resorption Bone remodeling 03 medical and health sciences 0302 clinical medicine Osteoclast Internal medicine Cell Adhesion medicine Animals Humans Bone Resorption Molecular Biology business.industry Cell Biology medicine.disease 030104 developmental biology Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis Podosomes Signal transduction business Signal Transduction |
| Zdroj: | Biochemical and Biophysical Research Communications. 476:115-120 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2016.05.019 |
| Popis: | Bone resorption is an important cellular function in skeletal development and remodeling of the adult skeleton. Most of the pathological bone disease conditions like osteoporosis reflect increased osteoclast activity; hence, increased bone resorption. Researchers have unraveled most of the intracellular mechanisms responsible for osteoclast bone-resorbing activity in last few decades. Therefore, understanding the fundamentals of osteoclast-induced bone resorption and the cytokines and other substances that modulate the osteoclast activity unequivocally provide insights into the development of drugs to ameliorate pathological bone diseases with enhanced bone resorption. The aim of this review is to examine the literature on osteoclast function and bone-resorbing activity. |
| Databáze: | OpenAIRE |
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