Epididymal Interstitial (Leydig) Cell Tumors in B6C3F1 Mice
| Autor: | M. R. Elwell, F. A. Talley, Kunitoshi Mitsumori |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Cell type 040301 veterinary sciences Cell Mice Inbred Strains Biology Interstitial cell Metastasis Rodent Diseases 0403 veterinary science Mice 03 medical and health sciences Testicular Neoplasms medicine Animals Epididymis General Veterinary Leydig cell 04 agricultural and veterinary sciences medicine.disease Basophilic Microscopy Electron 030104 developmental biology medicine.anatomical_structure Cytoplasm Sarcoma Leydig Cell Tumor |
| Zdroj: | Veterinary Pathology. 26:65-69 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/030098588902600110 |
| Popis: | Six primary interstitial cell tumors of the epididymis were identified from 46,752 male B6C3F, mice used in chronic toxicity and carcinogenicity studies. Five of the tumors occurred at the end of 2-year studies; none were attributed to treatment. None of the mice with epididymal tumors had a primary testicular tumor. Histologically, tumors were characterized by a nodular or diffuse proliferation of tumor cells in the epididymal interstitium. Most cells were polygonal with highly vacuolated cytoplasm (vacuolated cells) or eosinophilic cytoplasm (eosinophilic cells). Smaller hyperchromatic cells with scant basophilic cytoplasm (ba- sophilic cells) and cells with yellow-brown pigment characteristic of lipofuscin (pigmented cells) were less common. In each tumor two or more cell types were present. Extension of these tumors through the capsule, invasion of the testis, or metastasis did not occur. By electron microscopy both eosinophilic and vacuolated cell types had a large round or oval nucleus with sparse heterochromatin, abundant mitochondria with tubu- lovesicular cristae, and frequent desmosome structures between cell membranes. Vacuolated cells contained numerous lipid droplets. Morphological features of the epididymal tumors are similar to those of the testicular interstitial (Leydig) cell tumor in mice and rats. Spontaneous tumors of the epididymis are rare in mice. Schwannoma, l3 sarcoma,6J0 lipoma,6 and hem- angiosarcoma6 have been described. Although spon- taneous interstitial (Leydig) cell tumors in the testis occur in mice, interstitial tumors originating in the epididymis of mice or other species have not been described. Here, we report the gross, histopathologic, and ultrastructural features of primary epididymal in- terstitial cell tumors in B6C3F, mice. |
| Databáze: | OpenAIRE |
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