| Autor: |
O G Fitzhugh, Arthur A. Nelson |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 61 |
| ISSN: |
0037-9727 |
| Popis: |
SummaryWhen l-ascorbyl palmitate and d-isoascorbyl palmitate were fed subacutely for 9 months in concentrations of 2% and 5% of the diet, only the 5% levels were toxic. The growth rates of rats on the 5% levels were significantly retarded and bladder stones were produced in 2 animals on the 5% 1-ascorbyl palmitate. d-Isoascorbie acid in a concentration of 1% of the diet had no deleterious effect. Chronic toxicity studies for 2 years indicate that 1-ascorbyl and d-isoascorbyl palmitate are not toxic in concentrations of 0.25% (2500 p.p.m.), or less, of the total diet of rats. Heat-treating fresh lard containing the palmitates before adding it to the diet had no effect on toxicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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