Differential stimulus coupling to dopamine and norepinephrine stores in rabbit carotid body type I cells
| Autor: | A. Gomez-Nin˜o, B. Dinger, C. Gonzalez, S.J. Fidone |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Nicotine
medicine.medical_specialty Sympathetic Nervous System Dopamine In Vitro Techniques Biology Stimulus (physiology) Tritium Norepinephrine Internal medicine medicine Animals Molecular Biology Carotid Body General Neuroscience Arterial chemoreceptor Oxygen medicine.anatomical_structure Endocrinology Catecholamine Excitatory postsynaptic potential 3 4-Dihydroxyphenylacetic Acid Carotid body Rabbits Neurology (clinical) Type i cells Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 525:160-164 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(90)91334-d |
| Popis: | Recent studies suggest that preneural type I (glomus) cells in the arterial chemoreceptor tissue of the carotid body act as primary transducer elements which respond to natural stimuli (low O2, pH or increased CO2) by releasing chemical transmitter agents capable of exciting the closely apposed afferent nerve terminals. These type I cells contain multiple putative transmitters, but the identity of the natural excitatory agents remains an unresolved problem in carotid body physiology. Characterization of putative transmitter involvement in the response to natural and pharmacological stimuli has therefore become fundamental to further understanding of chemotransmission in this organ. The present study demonstrates that a natural stimulus (hypoxia) evokes the release of dopamine (DA) and norepinephrine (NE) in approximate proportion to their unequal stores in rabbit carotid body (DA release/NE release = 8.2). In contrast, nicotine (100 microM), a cholinomimetic agent thought to act on the nicotinic receptors present on the type I cells, evokes the preferential release of NE (DA release/NE release = 0.17). These findings suggest that distinct mechanisms are involved in a differential mobilization of these two catecholamines from the rabbit carotid body. |
| Databáze: | OpenAIRE |
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