Induced production of new diterpenoids in the fungus Penicillium funiculosum
| Autor: | Qiang Liu, Bo-Wen Liang, Xiao-Fei Li, Dong-Ze Liu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
biology Epigenetic modifier Chemistry Penicillium Plant Science General Medicine Fungus biology.organism_classification Methyltransferase inhibitor Epigenesis Genetic chemistry.chemical_compound Complementary and alternative medicine Biochemistry Biosynthesis Cell Line Tumor Drug Discovery Azacitidine Humans Penicillium funiculosum Epigenetics Diterpenes |
| Zdroj: | Natural product communications. 9(5) |
| ISSN: | 1934-578X |
| Popis: | The supplementation of a DNA methyltransferase inhibitor, 5-azacytidine (5-AZ), to the culture medium of Penicillium funiculosum, dramatically altered its metabolic profiles. Analysis of the culture broth extract led to the isolation of two new prenyleudesmane diterpenoids (1-2). The isolated compounds were further evaluated for their cytotoxic and antibacterial activities. Our findings confirmed that the use of chemical epigenetic modifiers is an effective technique for promoting the expression of silent biosynthetic pathways to produce unique secondary metabolites. |
| Databáze: | OpenAIRE |
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