Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics
| Autor: | Graham C. Walker, James J. Collins, James J. Foti, Babho Devadoss, Jonathan A. Winkler |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
DNA
Bacterial Guanine medicine.drug_class DNA polymerase II Antibiotics DNA polymerase beta DNA-Directed DNA Polymerase Biology Models Biological Article DNA Glycosylases chemistry.chemical_compound Kanamycin Escherichia coli medicine DNA Breaks Double-Stranded Pyrophosphatases Cytotoxicity DNA Polymerase beta Microbial Viability Multidisciplinary Hydroxyl Radical Escherichia coli Proteins Deoxyguanine Nucleotides DNA Polymerase II DNA Polymerase I Guanine Nucleotides Anti-Bacterial Agents RNA Bacterial chemistry Biochemistry DNA glycosylase DNA polymerase IV biology.protein Ampicillin Oxidation-Reduction DNA Norfloxacin |
| Zdroj: | Science. 336:315-319 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1219192 |
| Popis: | A Specific Oxidative Catastrophe Three different classes of antibiotics induce bacterial cell death by the production of hydroxyl radicals. Hydroxyl radicals are powerful oxidizing agents in living cells and will oxidize the nucleic acid base, guanine, to form 8-oxoguanine, which is potentially mutagenic because it can pair with both cytosine and adenine and form lethal double-strand DNA breaks. Foti et al. (p. 315 ) discovered that overproduction of the nucleotide sanitizer MutT, which hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, gives striking protection against cell death. |
| Databáze: | OpenAIRE |
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