Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

Autor: Samantha Toth, Víctor Granados-García, Jorge Salmerón, Arely Briseño-Pérez, Paula Ramírez-Palacios, William J McCarthy, Catherine M. Crespi, Yvonne N Flores
Přispěvatelé: Guerrero-Romero, Fernando
Rok vydání: 2020
Předmět:
Male
Mexican People
Cross-sectional study
Physiology
Epidemiology
Blood Pressure
Overweight
Vascular Medicine
Body Mass Index
0302 clinical medicine
Endocrinology
Risk Factors
Medicine and Health Sciences
Prevalence
Ethnicities
030212 general & internal medicine
Longitudinal Studies
Health Workforce
2. Zero hunger
Metabolic Syndrome
Multidisciplinary
Diabetes
Population groupings
Middle Aged
Blood Sugar
3. Good health
Body Fluids
Stroke
Chemistry
Blood
Physiological Parameters
Cohort
Physical Sciences
Medicine
Female
medicine.symptom
Anatomy
Cohort study
Research Article
Adult
medicine.medical_specialty
Endocrine Disorders
General Science & Technology
Science
030209 endocrinology & metabolism
Prediabetic State
03 medical and health sciences
Clinical Research
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Humans
Obesity
Mexico
Metabolic and endocrine
Nutrition
business.industry
Prevention
Body Weight
Chemical Compounds
Biology and Life Sciences
Latin American people
medicine.disease
Uric Acid
Cross-Sectional Studies
Metabolic Disorders
Medical Risk Factors
Metabolic syndrome
People and places
business
Body mass index
Acids
Zdroj: PloS one, vol 15, iss 3
PLoS ONE, Vol 15, Iss 3, p e0229403 (2020)
PLoS ONE
Popis: AimTo determine the association between known risk factors (e.g., obesity, metabolic syndrome and its components) and the development of pre-diabetes or diabetes over time in a cohort of Mexican health workers.MethodsParticipants in the Mexican Health Worker Cohort Study with complete information at two waves of data collection, 2004-2006 (W1) and 2011-2013 (W2), were included in the analysis (n = 1,174). Multivariable binary and multinomial logistic regression were used to examine the cross-sectional associations between specific risk factors and diabetes status (diabetes, pre-diabetes, or neither) at W1 and the longitudinal associations between changes in risk factors and progression of diabetes status from W1 to W2, respectively.ResultsMean time between waves was 7.0 years (SD 1.1). Prevalence of pre-diabetes and diabetes was 16% and 10% at W1 and increased to 30% and 16% at W2, respectively. The cross-sectional prevalence of pre-diabetes and diabetes was significantly higher among men, participants over the age of 45 years, and individuals who were overweight or obese or had metabolic syndrome (MS), three or more components of the MS, elevated alanine aminotransferase (ALT) levels, or elevated uric acid. In longitudinal analyses, remaining obese or gaining weight between waves was associated with an increased risk of developing pre-diabetes. A greater risk of developing pre-diabetes or diabetes was also observed among individuals who either maintained or acquired MS, elevated ALT, or elevated uric acid (only for diabetes) from W1 to W2.ConclusionsWeight gain and acquiring or maintaining MS, elevated ALT levels, or elevated uric acid were associated with a significant risk of developing pre-diabetes or diabetes. Our findings, especially in the context of the obesity epidemic in Mexico, point towards an urgent need for initiatives to help reduce excess weight in order to avert future cases of pre-diabetes and diabetes.
Databáze: OpenAIRE
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