Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case–control comparisons and a meta-analysis of published VDR data
| Autor: | Anthony J. Swerdlow, Yu-Mei Chang, Julia A. Newton Bishop, Julian H. Barth, Susan Leake, Chandra Bertram, Faye Elliott, Edwina Gerry, Paul Affleck, John C. Taylor, Isabel dos Santos Silva, Samantha Beswick, Jerry Marsden, Birute Karpavicius, Jennifer H. Barrett, D. Timothy Bishop, Kairen Kukalizch, Linda Bale, Helen P. Field, Juliette Randerson-Moor, Peter A. Kanetsky, Sue Haynes |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Adolescent Statistics as Topic Single-nucleotide polymorphism GATA Transcription Factors Polymerase Chain Reaction Polymorphism Single Nucleotide Calcitriol receptor Article Body Mass Index Specimen Handling Young Adult Gene Frequency Internal medicine medicine Vitamin D and neurology Humans CDX2 Transcription Factor Genetic Predisposition to Disease Obesity Vitamin D Allele Deoxyribonucleases Type II Site-Specific Hair Color Melanoma Allele frequency Alleles Aged Homeodomain Proteins biology Case-control study Odds ratio Middle Aged United Kingdom FokI Endocrinology Case-Control Studies biology.protein Receptors Calcitriol Female |
| Zdroj: | European Journal of Cancer. 45:3271-3281 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2009.06.011 |
| Popis: | We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D(3) levels in order to investigate the role of vitamin D in melanoma susceptibility. There was no significant evidence of an association between any VDR SNP and risk in 1028 population-ascertained cases and 402 controls from Leeds, UK. In a second Leeds case-control study (299 cases and 560 controls) the FokI T allele was associated with increased melanoma risk (odds ratio (OR) 1.42, 95% confidence interval (CI) 1.06-1.91, p=0.02). In a meta-analysis in conjunction with published data from other smaller data sets (total 3769 cases and 3636 controls), the FokI T allele was associated with increased melanoma risk (OR 1.19, 95% CI 1.05-1.35), and the BsmI A allele was associated with a reduced risk (OR 0.81, 95% CI 0.72-0.92), in each instance under a parsimonious dominant model. In the first Leeds case-control comparison cases were more likely to have a higher body mass index (BMI) than controls (p=0.007 for linear trend). There was no evidence of a case-control difference in serum 25-hydroxyvitamin D(3) levels. In 1043 incident cases from the first Leeds case-control study, a single estimation of serum 25-hydroxyvitamin D(3) level taken at recruitment was inversely correlated with Breslow thickness (p=0.03 for linear trend). These data provide evidence to support the view that vitamin D and VDR may have a small but potentially important role in melanoma susceptibility, and putatively a greater role in disease progression. |
| Databáze: | OpenAIRE |
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