Reproductive outcomes of intracytoplasmic sperm injection using testicular sperm and ejaculated sperm in patients with AZFc microdeletions: a systematic review and meta-analysis
| Autor: | Xinzong Zhang, Huang Liu, Yu Zhou, Yunge Tang, Jun-Hong Deng, Wujiang Liu, Houbin Zheng, Cuncan Deng |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male endocrine system Sperm Retrieval Urology medicine.medical_treatment Sex Chromosome Disorders of Sex Development assisted reproductive technology azoospermia factor c microdeletions ejaculated sperm live birth rate testicular sperm Intracytoplasmic sperm injection Andrology medicine Humans Sperm Injections Intracytoplasmic Infertility Male Sex Chromosome Aberrations reproductive and urinary physiology Retrospective Studies Azoospermia factor Chromosomes Human Y Assisted reproductive technology urogenital system business.industry General Medicine Spermatozoa Sperm Diseases of the genitourinary system. Urology Confidence interval Treatment Outcome Relative risk Meta-analysis Original Article RC870-923 Genetic Fitness Chromosome Deletion Live birth business |
| Zdroj: | Asian Journal of Andrology Asian Journal of Andrology, Vol 23, Iss 5, Pp 495-500 (2021) |
| ISSN: | 1008-682X |
| DOI: | 10.4103/aja.aja_1_21 |
| Popis: | Studies have explored the assisted reproductive technology (ART) outcomes of Y-chromosome azoospermia factor c (AZFc) microdeletions, but the effect of sperm source on intracytoplasmic sperm injection (ICSI) remains unknown. To determine the ART results of ICSI using testicular sperm and ejaculated sperm from males with AZFc microdeletions, we searched Embase, Web of Science, and PubMed to conduct a systematic review and meta-analysis. The first meta-analysis results for 106 cycles in five studies showed no significant differences in the live birth rate between the testicular sperm group and the ejaculated sperm group (risk ratio: 0.97, 95% confidence interval [CI]: 0.73–1.28, P = 0.82). The second meta-analysis of 106 cycles in five studies showed no difference in the abortion rate between the testicular sperm group and ejaculated sperm group (risk ratio: 1.06, 95% CI: 0.54–2.06, P = 0.87). The third meta-analysis of 386 cycles in seven studies showed no significant difference in clinical pregnancy rates between the testicular sperm group and the ejaculated sperm group (risk ratio: 1.24, 95% CI: 0.66–2.34, P = 0.50). Inevitable heterogeneity weakened our results. However, our results indicated that testicular sperm and ejaculated sperm yield similar ART outcomes, representing a meaningful result for clinical treatment. More properly designed studies are needed to further confirm our conclusions. |
| Databáze: | OpenAIRE |
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