Neural Correlates of Own Name and Own Face Detection in Autism Spectrum Disorder

Autor: Paweł Ostaszewski, Hanna B. Cygan, Izabela Chojnicka, Anna Nowicka, Pawel Tacikowski
Rok vydání: 2014
Předmět:
Anatomy and Physiology
Neuropsychological Tests
Audiology
Electroencephalography
Social and Behavioral Sciences
Pediatrics
Cognition
Child Development
Names
Psychology
Attention
Evoked Potentials
Clinical Neurophysiology
Multidisciplinary
medicine.diagnostic_test
Child Health
Brain
Experimental Psychology
Electrophysiology
Clinical Psychology
Pattern Recognition
Visual
Autism spectrum disorder
Medicine
Public Health
Research Article
Adult
medicine.medical_specialty
Adolescent
Consciousness
Social Psychology
Cognitive Neuroscience
Science
Biology
behavioral disciplines and activities
Lateralization of brain function
Young Adult
Diagnostic Medicine
Event-related potential
Social cognition
mental disorders
medicine
Humans
Analysis of Variance
Neural correlates of consciousness
Recognition
Psychology
medicine.disease
Event-Related Potentials
P300
Self Concept
Social relation
Child Development Disorders
Pervasive
Face
Autism
Photic Stimulation
Neuroscience
Zdroj: PLoS ONE, Vol 9, Iss 1, p e86020 (2014)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0086020
Popis: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition clinically characterized by social interaction and communication difficulties. To date, the majority of research efforts have focused on brain mechanisms underlying the deficits in interpersonal social cognition associated with ASD. Recent empirical and theoretical work has begun to reveal evidence for a reduced or even absent self-preference effect in patients with ASD. One may hypothesize that this is related to the impaired attentional processing of self-referential stimuli. The aim of our study was to test this hypothesis. We investigated the neural correlates of face and name detection in ASD. Four categories of face/name stimuli were used: own, close-other, famous, and unknown. Event-related potentials were recorded from 62 electrodes in 23 subjects with ASD and 23 matched control subjects. P100, N170, and P300 components were analyzed. The control group clearly showed a significant self-preference effect: higher P300 amplitude to the presentation of own face and own name than to the close-other, famous, and unknown categories, indicating preferential attentional engagement in processing of self-related information. In contrast, detection of both own and close-other's face and name in the ASD group was associated with enhanced P300, suggesting similar attention allocation for self and close-other related information. These findings suggest that attention allocation in the ASD group is modulated by the personal significance factor, and that the self-preference effect is absent if self is compared to close-other. These effects are similar for physical and non-physical aspects of the autistic self. In addition, lateralization of face and name processing is attenuated in ASD, suggesting atypical brain organization.
Databáze: OpenAIRE
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