High expression of the bcl-x gene in Reed-Sternberg cells of Hodgkin's disease
| Autor: | Georges Delsol, Jacques Pris, Michel March, John C. Reed, Pierre Brousset, Stanislaw Krajewski, Guy Laurent, Daniel Schlaifer |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Herpesvirus 4
Human Pathology medicine.medical_specialty Lymphocyte Immunology bcl-X Protein In situ hybridization Biology Biochemistry Pathogenesis Nodular sclerosis Proto-Oncogene Proteins hemic and lymphatic diseases Gene expression medicine Humans Reed-Sternberg Cells Retrospective Studies Cell Biology Hematology medicine.disease Hodgkin Disease Immunohistochemistry Molecular biology Lymphoma medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Reed–Sternberg cell DNA Viral Lymph Nodes |
| Zdroj: | Blood. 85:2671-2674 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v85.10.2671.bloodjournal85102671 |
| Popis: | The expression of bcl-x protein, a bcl-2-related protein present in cortical thymocytes, activated lymphocytes, and plasma cells of reactive lymph nodes, was investigated in 44 cases of Hodgkin's disease (HD) in parallel with bcl-2 and Epstein-Barr virus (EBV) status. Eighty-six percent of the cases were positive for bcl-x, among them 27% with a strong signal in more than 75% of the Reed-Sternberg cells. Positivity for bcl-x was found in, respectively, 100% and 92% of the nodular sclerosis and mixed cellularity subtypes, although 4 cases of lymphocyte predominance subtype were negative. This finding was in contrast with the weaker positivity for bcl-2 staining in 44% of the cases. EBV small RNAs were detected in 43% of the cases by using in situ hybridization. Of interest, 100% of the EBV-positive samples were positive for bcl-x, whereas only 38% of these cases were bcl-2 positive. Our findings show that the bcl-x gene expression is high in HD, suggesting that bcl-x may have a role in the pathogenesis of at least some cases of HD via apoptosis regulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|