Comparison of Waterless Hand Antisepsis Agents at Short Application Times: Raising the Flag of Concern

Autor: Sasi Dharan, Stéphane Hugonnet, Didier Pittet, Hugo Sax
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Microbiology (medical)
Staphylococcus aureus
medicine.medical_specialty
Time Factors
European norm
Epidemiology
medicine.drug_class
media_common.quotation_subject
Ethanol/administration & dosage/ pharmacology
Enterococcus faecalis
Pseudomonas aeruginosa/isolation & purification
Teaching hospital
Handwashing/ methods/ standards
Antiseptic
Hygiene
Internal medicine
medicine
Infection control
Humans
media_common
ddc:616
Cross-Over Studies
Ethanol
biology
business.industry
Single application
biology.organism_classification
Crossover study
Surgery
Infectious Diseases
Treatment Outcome
Enterococcus faecalis/isolation & purification
Staphylococcus aureus/isolation & purification
Pseudomonas aeruginosa
Anti-Infective Agents
Local
Anti-Infective Agents
Local/administration & dosage/ pharmacology
business
Gels
Hand Disinfection
Zdroj: Infection Control and Hospital Epidemiology, Vol. 24, No 3 (2003) pp. 160-164
ISSN: 0195-9417
0899-823X
Popis: Objective:Although alcohol-based hand rinses and gels have recommended application times of 30 to 60 seconds, healthcare workers usually take much less time for hand hygiene. We compared the efficacies of four alcohol-based hand rubs produced in Europe (hand rinses A, B, and C and one gel formulation) with the efficacy of the European Norm 1500 (EN 1500) reference waterless hand antisepsis agent (60% 2-propanol) at short application times.Design:Comparative crossover study.Setting:Infection Control Program laboratory of a large tertiary-care teaching hospital.Participants:Twelve healthy volunteers.Intervention:Measurement of residual bacterial counts and log reduction factors following inoculation of fingertips with Staphylococcus aureus American Type Culture Collection (ATCC) 6538, Pseudomonas aeruginosa ATCC 15442, and a clinical isolate of Enterococcus faecalis.Results:All hand rinses satisfied EN 1500 standards following a single application for 15 and 30 seconds, but reduction factors for the gel formulation were significantly lower for all tested organisms (all P < .025).Conclusions:Under stringent conditions similar to clinical practice, all three hand rinses proved to be more efficacious than the marketed alcohol-based gel in reducing bacterial counts on hands. Further studies are necessary to determine the in vivo efficacy of alcohol-based gels and whether they are as efficacious as alcohol-based rinses in reducing the transmission of nosocomial infections.
Databáze: OpenAIRE
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