Curative Effect of Aqueous Leaf Extract of Crinum Giganteum on NMDA-Receptor Antagonist-Induced Schizophrenic Wistar Rat Model
| Autor: | Anyanwu Emeka Godson, Esom Emmanuel Anayochukwu, Elizabeth Finbarrs-Bello, EN Obikili |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_treatment
Enolase lcsh:Medicine Pharmacology Haematoxylin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Basic Science NSE Crinum Medicine 030212 general & internal medicine Chlorpromazine Saline Psychiatry Eosin biology business.industry lcsh:R Ketamine hydrochloride General Medicine Amygdala Crinum giganteum Amy Chlorpromazine Schizophrenia NMDA biology.organism_classification chemistry nervous system Anesthesia NMDA receptor business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences, Vol 4, Iss 3, Pp 337-341 (2016) Open Access Macedonian Journal of Medical Sciences; Vol 4, No 3 (2016): Sep 15 (OAMJMS); 337-341 Open Access Macedonian Journal of Medical Sciences Open Access Macedonian Journal of Medical Sciences; Vol. 4 No. 3 (2016): Sep 15 (OAMJMS); 337-341 |
| ISSN: | 1857-9655 |
| Popis: | AIM: This study evaluated the curative potential of Crinum giganteum in the treatment of schizophrenia using an NMDA-receptor antagonist-induced schizophrenic Wistar rat model. METHODS: Twenty-five adult Wistar rats of both sexes of average weights 180 g were divided into two groups: control and schizophrenic rat models. The controls received 0.1 ml of 0. 9% saline, while schizophrenia was induced in models using 25 mg/kg of ketamine hydrochloride (i.p.) for 7 days. On the 8 day models were divided into group’s k1, k2, k3 and k4 of 5 rats each. K1 and the controls were sacrificed then, groups k2 and k3 were treated with 5 mg/kg and 10 mg/kg aqueous leaf extract of Crinum giganteum while, k4 (standard) received 25 mg/kg of chlorpromazine orally for 28 days. Amygdala were harvested, processed and stained with Haematoxylin and Eosin (H &E) stain, Neuron-specific enolase (NSE) marker was also used to monitor the curative effect on the amygdala.RESULTS: Degenerative changes and increased NSE immunoreactivity were observed in the untreated models. Extract-treated models showed normal amygdala and negative NSE immunoreactivity while chlorpromazine treated models revealed decreased NSE immunoreactivity.CONCLUSION: Crinum giganteum extracts exhibits better curative effect than the standard antipsychotic agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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