Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasia
| Autor: | Lynn A. Dowdell, Arthur L. M. Swislocki, Dana E. Wilson, Omar Caticha, Robert H. Noth, Jacques J. Lamothe, Roger Barrow, William D. Odell |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Cortisol secretion endocrine system medicine.medical_specialty Hydrocortisone medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Biochemistry Mice Cushing syndrome chemistry.chemical_compound Endocrinology Pregnancy Corticosterone Internal medicine medicine Animals Humans Cushing Syndrome Cells Cultured Analysis of Variance Dose-Response Relationship Drug Estradiol business.industry Adrenal cortex Biochemistry (medical) medicine.disease Pregnancy Complications Steroid hormone medicine.anatomical_structure chemistry Estrogen Immunoglobulin G Adrenal Cortex Biological Assay Female business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 77:494-497 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.77.2.8345057 |
| Popis: | Adrenal glands from a patient with ACTH-independent Cushing's syndrome, whose symptoms worsened during pregnancy and oral contraceptive use, were cultured in different concentrations of estradiol. Estradiol stimulated cortisol secretion in a dose-response manner in the absence of ACTH. Since immunoglobulins G from this patient did not stimulate corticosterone production in a mouse adrenal bioassay, an adrenal-stimulating immunoglobulin is unlikely to be the cause of adrenal hyperfunction in this case. This is the first description of estradiol stimulation of cortisol production by cultured adrenal cells in ACTH-independent Cushing's syndrome. |
| Databáze: | OpenAIRE |
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