Musings on the wanderer: What’s new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism
| Autor: | Bret N. Smith, M Soledad Pitra |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Dorsum Cell signaling Nucleus tractus solitarius Physiology Review Biology Carbohydrate metabolism 03 medical and health sciences 0302 clinical medicine Physiology (medical) Reflex Neuroplasticity Animals Humans Neurons Hepatology Gastroenterology Vagus Nerve Crosstalk (biology) Glucose 030104 developmental biology Digestive System Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Am J Physiol Gastrointest Liver Physiol |
| ISSN: | 1522-1547 0193-1857 |
| DOI: | 10.1152/ajpgi.00368.2020 |
| Popis: | Neurons in the brain stem dorsal vagal complex (DVC) take part in a continuous bidirectional crosstalk, in which they receive and respond to a vast array of signaling molecules, including glucose. Importantly, chronic dysregulation of blood glucose concentration, a hallmark of high prevalence pathologies, such as diabetes and metabolic syndrome, can induce neuroplasticity in DVC neural networks, which is hypothesized to either contribute to or compensate for the glycemic or insulinemic dysregulation observed in these conditions. Here, we revisit the topic of vagal reflexes to review recent research on the importance of DVC function in regulating systemic glucose homeostasis and the neuroplastic changes in this brain region that are associated with systemic glucose alterations. We also discuss the critical connection between these nuclei and the gut and the role of central vagal circuits in the favorable outcomes associated with bariatric surgical procedures for metabolic disorders. |
| Databáze: | OpenAIRE |
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