Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach
| Autor: | Ronald Kuczenski, Thomas B. Barrett, John R. Kelsoe, Alexander B. Niculescu, David S. Segal, Richard L. Hauger |
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| Rok vydání: | 2000 |
| Předmět: |
Candidate gene
Psychosis Bipolar Disorder G-Protein-Coupled Receptor Kinase 3 Physiology Vesicular Transport Proteins Nerve Tissue Proteins Protein Serine-Threonine Kinases Biology Rats Sprague-Dawley Genetics medicine Animals Humans Bipolar disorder Insulin-Like Growth Factor I Caenorhabditis elegans Proteins Adaptor Proteins Signal Transducing Sequence Homology Amino Acid Membrane Proteins Genomics Helminth Proteins medicine.disease Arylsulfotransferase Rats Farnesyl-Diphosphate Farnesyltransferase Psychotic Disorders Schizophrenia Gene chip analysis Sulfotransferases DNA microarray medicine.symptom Oxidoreductases Functional genomics Mania Signal Transduction |
| Zdroj: | Physiological Genomics. 4:83-91 |
| ISSN: | 1531-2267 1094-8341 |
| DOI: | 10.1152/physiolgenomics.2000.4.1.83 |
| Popis: | We have used methamphetamine treatment of rats as an animal model for psychotic mania. Specific brain regions were analyzed comprehensively for changes in gene expression using oligonucleotide GeneChip microarrays. The data was cross-matched against human genomic loci associated with either bipolar disorder or schizophrenia. Using this convergent approach, we have identified several novel candidate genes (e.g., signal transduction molecules, transcription factors, metabolic enzymes) that may be involved in the pathogenesis of mood disorders and psychosis. Furthermore, for one of these genes, G protein-coupled receptor kinase 3 (GRK3), we found by Western blot analysis evidence for decreased protein levels in a subset of patient lymphoblastoid cell lines that correlated with disease severity. Finally, the classification of these candidate genes into two prototypical categories, psychogenes and psychosis-suppressor genes, is described. |
| Databáze: | OpenAIRE |
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