Platinum Doublet plus Atezolizumab as First-line Treatment in Metastatic Large Cell Neuroendocrine Carcinoma: A Single Institution Experience
Autor: | Sofia C. Economidou, Konstantinos Vrontis, George Fotopoulos |
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Rok vydání: | 2021 |
Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Antibodies Monoclonal Humanized Small-cell carcinoma Atezolizumab Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans Medicine Prospective Studies Neoplasm Metastasis Prospective cohort study Lung cancer Etoposide Aged Platinum Retrospective Studies Chemotherapy Lung business.industry General Medicine Middle Aged Large cell neuroendocrine carcinoma of the lung medicine.disease Small Cell Lung Carcinoma Survival Analysis Carcinoma Neuroendocrine Treatment Outcome medicine.anatomical_structure Carcinoma Large Cell business medicine.drug |
Zdroj: | Cancer Investigation. 40:124-131 |
ISSN: | 1532-4192 0735-7907 |
DOI: | 10.1080/07357907.2021.1988962 |
Popis: | BACKGROUND Large Cell Neuroendocrine Carcinoma of the Lung (L-LCNEC) is a rare type of neuroendocrine lung cancer that is increasingly diagnosed. However, the optimal management regarding the advanced stage is unclear. The purpose of this article is to present and compare our experience when L-LCNEC is treated as Small Cell Lung Cancer (SCLC). PATIENTS AND METHODS Overall, eight cases of L-LCNEC were included. We retrospectively reviewed medical files and reports by accessing the Institution's Data of patients diagnosed with L-LCNEC from April 2019 until December 2020 and evaluated their response to the combination of Platinum - Etoposide - Atezolizumab as first-line chemotherapy. RESULTS The overall observed response rate (ORR) of 75%. The median PFS was 6.85 months. The median response duration was 5.5 months. CONCLUSIONS Comparing our findings with other retrospective and prospective studies, it seems that the systematic treatment of choice and management in L-LCNEC of the lung should be that of a small cell carcinoma of the lung. |
Databáze: | OpenAIRE |
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