An Age and Gender Dependency of Metabolite Concentrations in Basal Ganglia in Children with Spastic Diplegia: Proton Magnetic Resonance Spectroscopy Study
| Autor: | Dorota Otapowicz, Bozena Kubas, Wojciech Sobaniec, Bozena Zawada, Joanna Smigielska-Kuzia, Wojciech Kułak |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Aging medicine.medical_specialty Magnetic Resonance Spectroscopy Adolescent Metabolite Creatine Basal Ganglia Statistics Nonparametric Choline Cerebral palsy chemistry.chemical_compound Internal medicine Spastic diplegia Basal ganglia Spastic medicine Humans Child Aspartic Acid Sex Characteristics business.industry Cerebral Palsy medicine.disease Magnetic Resonance Imaging Proton magnetic resonance Endocrinology chemistry Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Female Neurology (clinical) Protons business Neuroscience |
| Zdroj: | Journal of Child Neurology. 24:73-79 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/0883073808321058 |
| Popis: | We determined metabolite profile in spastic diplegic children compared to controls in left basal ganglia of brain in using proton magnetic resonance spectroscopy in correlation with age and gender. Twenty-four patients with spastic diplegia and twenty-six healthy children were examined. The relative concentrations of N-acetylaspartate, choline, and myoinositol were measured in relation to creatine and different combinations of metabolites within 8-cm3 brain voxel. Children with spastic diplegia showed reduced ratios of N-acetylaspartate/creatine, N-acetylaspartate/ choline, and N-acetylaspartate/myoinositol in the basal ganglia compared to the control group. Patients and controls subjects demonstrated a significant age-dependent increase in N-acetylaspartate/creatine, N-acetylaspartate/choline in the basal ganglia. No gender-dependent difference was shown in children with cerebral palsy for all tested metabolite ratios. Gender-related differences because of increased ratio N-acetylaspartate/choline in girls in controls were detected. These results indicate that maturation of brain exists in cerebral palsy and healthy children to a higher degree in healthy children. |
| Databáze: | OpenAIRE |
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