Giant cell arteritis associated with PD-1 inhibition
| Autor: | Jisna Paul, Nina Couette |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
medicine.medical_specialty
Giant Cell Arteritis Programmed Cell Death 1 Receptor Adenocarcinoma of Lung Pembrolizumab Antibodies Monoclonal Humanized Gastroenterology Internal medicine Synovitis medicine Humans Ultrasonography business.industry Antagonist Headache General Medicine Middle Aged medicine.disease Rheumatology Temporal Arteries Giant cell arteritis Methotrexate Female Vasculitis business Metastatic Lung Adenocarcinoma medicine.drug |
| Zdroj: | BMJ case reports. 14(11) |
| ISSN: | 1757-790X |
| Popis: | A 50-year-old woman was referred to rheumatology for new onset polyarthralgia and headache. She had a history of metastatic lung adenocarcinoma and was started on treatment with the programmed death 1 receptor (PD-1) antagonist pembrolizumab 2 months prior. Examination revealed left temporal artery tenderness and hand synovitis. Investigations revealed enlarged temporal artery on ultrasound imaging. On steroid treatment, she had resolution of symptoms, but due to significant steroid side effects required methotrexate and her PD-1 antagonist therapy was continued in consultation with her oncologist. Her malignant disease has remained stable, and she has improved functional status. |
| Databáze: | OpenAIRE |
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