Graft Survival Effect of Hla-A Allele Matching Parathyroid Allotransplantation

Autor: Yeliz Emine Ersoy, Emrah Yücesan, Adem Akçakaya, Harika Salepçioğlu Kaya, Beyza Goncu
Přispěvatelé: GÖNCÜ, BEYZA SERVET
Rok vydání: 2021
Předmět:
medicine.medical_specialty
medicine.medical_treatment
Parathyroid hormone
030209 endocrinology & metabolism
Gastroenterology
General Biochemistry
Genetics and Molecular Biology
Parathyroid Glands
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Transplantation
Homologous
030212 general & internal medicine
the official publication of the American Federation for Clinical Research
2020 [Goncu B.
Salepcioglu Kaya H.
Yucesan E.
Ersoy Y. E.
Akcakaya A.
-Graft survival effect of HLA-A allele matching parathyroid allotransplantation.-
Journal of investigative medicine]
Alleles
HLA-A Antigens
business.industry
Graft Survival
Panel reactive antibody
General Medicine
Parathyroid chief cell
medicine.disease
Transplantation
medicine.anatomical_structure
Hypoparathyroidism
Calcium
Parathyroid gland
business
Kidney disease
Allotransplantation
Zdroj: Journal of Investigative Medicine. 69:785-788
ISSN: 1708-8267
1081-5589
DOI: 10.1136/jim-2020-001648
Popis: Permanent hypoparathyroidism is an endocrine disease that is mostly associated with the disruption of the parathyroid glands during surgery. Allotransplantation is the most promising approach for treatment particularly for its cost-effective and exact curative potential. Herein our aim was to evaluate human leukocyte antigen (HLA)-A allele matching effect on clinical improvement and graft survival after parathyroid transplantation. We performed parathyroid transplantation between ABO/Rh compatible recipient and an unrelated donor who has chronic kidney disease. Preoperative immunological tests include panel reactive antibody, T-flow cytometry crossmatch, B-flow cytometry crossmatch, autoflow cytometry crossmatch, and complement-dependent cytotoxicity crossmatch tests were performed. After histopathological evaluation, half of the resected parathyroid gland cells were isolated and transplanted to the omentum surface by laparoscopy. The transplantation outcome was followed up throughout 382 days. The recipient discharged 2 days after transplantation without any complication. During follow-up, calcium and vitamin D supplementation reduced to a one-third dose; even the intact PTH levels remained low. However, clinical improvement was observed by serum calcium levels. The recipient still continues with low-dose supplementation after 382 days of post-transplantation. Parathyroid cell transplantation to the omental tissue is the most promising option even with only one allele matching for patients with using lifelong high-dose supplementation. Clinical improvements and long-term effect of HLA-A allele matching should be evaluated with more studies and in larger cohorts as well.
Databáze: OpenAIRE
Externí odkaz: