Developmental changes and regional localization of Dspp, Mepe, Mimecan and Versican in postnatal developing mouse teeth
| Autor: | Zong-Xia Liu, Kai-Liang Tang, Chao Hou, Jun Sun, M. G. Wang, Jiayong Wang, Shuai Li |
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| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Physiology Sialoglycoproteins Mice Versicans stomatognathic system medicine Animals Glycoproteins Regulation of gene expression Extracellular Matrix Proteins Mice Inbred BALB C biology Gene Expression Profiling Gene Expression Regulation Developmental Cell Biology General Medicine Phosphoproteins Immunohistochemistry Cell biology Odontoblast Proteoglycan Cytoplasm biology.protein MEPE Versican Pulp (tooth) Intercellular Signaling Peptides and Proteins Odontogenesis Developmental biology Tooth |
| Zdroj: | Journal of molecular histology. 43(1) |
| ISSN: | 1567-2387 |
| Popis: | It has been implicated noncollagenous proteins act as important regulators during odontogenesis. To test the hypothesis that the roles of Dspp, Mepe, Versican and Mimecan in the regulation of odontogenesis may be complementary, comparative investigations on the localization of four proteins were performed by immunohistochemical staining using mouse first molar at different developmental stages as a model. In postnatal 1- day-old mice, all the proteins, excluding Mepe, showed co-expression in young odontoblasts. At postnatal 3, strong immunoreactions for all proteins were detected in odontoblasts. Interestingly, Mepe was present within both cytoplasm and nucleus in odontoblasts. In mice older than 5 days, the expression of Dspp, Mimecan and Versican accumulated in subodontoblastic layer of the coronal pulp at high levels while the co-expression of Mepe and Mimecan significantly existed in predentin. The temporal-spatial specific pattern and unique co-localization of Dspp, Mepe, Mimecan and Versican suggest they play complementary roles during odontogenesis. |
| Databáze: | OpenAIRE |
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