Imaging time-of-flight secondary ion mass spectrometry of solid-phase peptide syntheses
| Autor: | Robert Combarieu, Jean-Louis Aubagnac, Jean Martinez, C. Drouot, Christine Enjalbal |
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| Přispěvatelé: | Laboratoire des Amino-acides Peptides et Protéines (LAPP), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Centre de Mise en Forme des Matériaux (CEMEF), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Spectrometry
Mass Secondary Ion Peptide Bead Mass spectrometry Chemical synthesis [SPI.MAT]Engineering Sciences [physics]/Materials chemistry.chemical_compound Phase (matter) Peptide synthesis Amino Acids Spectroscopy chemistry.chemical_classification Fluorenes imaging Combinatorial chemistry peptide Secondary ion mass spectrometry Resins Synthetic Time of flight Tof-SIMS chemistry supported synthesis visual_art visual_art.visual_art_medium Peptides combinatorial chemistry |
| Zdroj: | Journal of Mass Spectrometry Journal of Mass Spectrometry, Wiley-Blackwell, 1999, 34 (7), p.749-754. ⟨10.1002/(SICI)1096-9888(199907)34:73.0.CO;2-P⟩ |
| ISSN: | 1076-5174 1096-9888 |
| Popis: | International audience; Imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS) of solid-phase peptide syntheses carried out by the Merrifield and Sheppard strategies is described. Mixtures of resin beads mixed at random from batch syntheses or obtained in combinatorial chemistry by the mix and split technique, where each bead is functionalized by a unique peptide, were analyzed directly without any chemical cleavage of the growing chains to assess the nature of the growing structure on any bead of the mixture without its isolation. |
| Databáze: | OpenAIRE |
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