Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors
| Autor: | Ka-On Lam, Kai-Pun Wong, Victor Ho-Fun Lee, Horace Cheuk-Wai Choi, Wing-Lok Chan, Kwok-Keung Yuen, Brian Hung-Hin Lang, Dora L.W. Kwong |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Gerontology Adolescent 030209 endocrinology & metabolism Young Adult 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Asian People Cancer Survivors Survivorship curve Health care thyroid cancer medicine Humans follow up Thyroid Neoplasms Thyroid cancer RC254-282 Aged Neoplasm Staging Aged 80 and over Health related quality of life business.industry Age Factors Neoplasms. Tumors. Oncology. Including cancer and carcinogens Hematology General Medicine Middle Aged medicine.disease health care humanities quality of life Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Hong Kong Female business survivorship Research Article |
| Zdroj: | Cancer Control : Journal of the Moffitt Cancer Center Cancer Control, Vol 28 (2021) |
| ISSN: | 1073-2748 |
| DOI: | 10.1177/10732748211029726 |
| Popis: | Background: Health-related quality of life (HRQoL) is important for differentiated thyroid cancer survivors, but data for Asian survivors is lacking. This study aimed to have an overview of, and identify any disease-or treatment-related factors associated with, HRQoL in Asian differentiated thyroid cancer survivors. Patients and Methods: Thyroid cancer survivors were recruited from the thyroid clinics at Queen Mary Hospital, Hong Kong from February 2016 to December 2016. All adult differentiated thyroid cancer patients with stable disease more than or equal to 1 year received a survey on HRQoL using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Thyroid cancer specific quality of life (THYCA-QoL) questionnaire. Clinical information was collected retrospectively from the computerized clinical management system. To identify factors associated with poor HRQoL, univariable and stepwise multivariable regression analysis were performed. Results: A total of 613 survivors completed the questionnaires (response rate: 82.1%; female: 80.1%; median survivorship: 7.4 years (range: 1.0-48.2 years)). The QLQ-C30 summary score mean was 84.4 (standard deviation (SD): 12.7) while the THYCA-QoL summary score mean was 39.9 (SD: 9.7). The 2 highest symptom subscales were fatigue (mean: 26.4, SD: 20.6) and insomnia (mean: 26.2, SD: 27.6). Factors associated with worse HRQoL included serum thyrotropin (TSH) greater than 1.0 mIU/L, unemployment, and concomitant psychiatric disorders. Concomitant psychiatric illness (n = 40/613, 6.5%) also showed significant association with most of the symptom and functional subscales. Conclusions: Fatigue and insomnia were the 2 most common symptoms experienced by our differentiated thyroid cancer survivors. Long-term survivorship care with monitoring serum TSH level, supporting return-to-work and screening for concomitant psychiatric disorders should be offered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|