Camphor white oil induces tumor regression through cytotoxic T cell-dependent mechanisms
| Autor: | Blair A Jenkins, Aislyn M. Nelson, Sophie A Greenberg, David M. Owens, Yalda Moayedi, Lina V. Dimitrov, Kara L. Marshall, Ellen A. Lumpkin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Keratinocytes Cancer Research Skin Neoplasms Cell Cinnamomum camphora Inflammation Article law.invention Mice 03 medical and health sciences Camphor chemistry.chemical_compound 0302 clinical medicine Immune system Piperidines law In vivo Oils Volatile medicine Animals Humans Cytotoxic T cell Molecular Biology Cells Cultured Essential oil Calcium signaling Cell Proliferation 030304 developmental biology Anthracenes 0303 health sciences NFATC Transcription Factors biology NFAT biology.organism_classification 3. Good health 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research Female medicine.symptom T-Lymphocytes Cytotoxic |
| Zdroj: | Mol Carcinog |
| DOI: | 10.1101/386789 |
| Popis: | Bioactive derivatives from the camphor laurel tree, Cinnamomum camphora, are posited to exhibit chemopreventive properties but the efficacy and mechanism of these natural products have not been established. We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. We next investigated underlying cellular and molecular mechanisms. In cultured keratinocytes, CWO stimulated calcium signaling, resulting in calcineurin-dependent activation of nuclear factor of activated T cells (NFAT). In vivo, CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. Finally, we identified chemical constituents of CWO that recapitulated effects of the admixture. Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden.SUMMARY BLURBEssential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. |
| Databáze: | OpenAIRE |
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