Widespread granuloma annulare and Hodgkin's disease
| Autor: | G. Lepeu, A. Azzedine, Ali Dadban, B. Slama |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty Population Dermatology Disease Granuloma Annulare Antineoplastic Combined Chemotherapy Protocols medicine Humans education Granuloma annulare Salvage Therapy Hodgkin s education.field_of_study medicine.diagnostic_test business.industry Cancer Middle Aged medicine.disease Hodgkin Disease Pathophysiology Lymphoma Treatment Outcome Positron emission tomography Positron-Emission Tomography business Stem Cell Transplantation |
| Zdroj: | Clinical and experimental dermatology. 33(4) |
| ISSN: | 1365-2230 |
| Popis: | The presence of coexistent disseminated granuloma annulare (GA) and Hodgkin's disease (HD) is rare, with only six reported patients to date. We describe a patient with HD who had limited GA 2 years before the diagnosis of HD; widespread GA appeared after first-line treatment and heralded disease relapse. GA lesions showed hypermetabolic images on positron emission tomography, an interesting finding of unknown significance. We suggest a new pathophysiological mechanism for this association, i.e. that the reactive T-lymphocyte population in HD may contribute to granuloma formation through the secretion of cytokines and the subsequent upregulation of certain metalloproteinases. Diffuse cutaneous GA should raise the possibility of underlying systemic lymphoma or HD. |
| Databáze: | OpenAIRE |
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