Relationship between the Severity of Inflammatory Changes in Chronic Sinusitis and the Level of Vitamin D before and after the FESS Procedure

Autor:	Kamil Radajewski, Paulina Kalińczak-Górna, Paweł K. Burduk
Rok vydání:	2021
Předmět:	medicine.medical_specialty Inflammation vitamin D Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Internal medicine chronic sinusitis Vitamin D and neurology medicine In patient 030212 general & internal medicine Stage (cooking) 030223 otorhinolaryngology Nasal endoscopy medicine.diagnostic_test business.industry Chronic sinusitis General Medicine Endoscopy Paranasal sinuses medicine.anatomical_structure inflammation FESS procedure Medicine medicine.symptom business
Zdroj:	Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 2836, p 2836 (2021) Volume 10 Issue 13
ISSN:	2077-0383
Popis:	There have been a few reports confirming that vitamin D (VD3) deficiency increases inflammation in the paranasal sinuses. The work brings new information that, despite the presence of inflammation before surgery, patients with higher vitamin D levels had less inflammation, and this has been proven on three levels. We show that vitamin D levels clearly correlate with the severity of the disease in chronic sinusitis. These results have been confirmed in imaging studies (Lund MacKay scale), endoscopy (Lund-Kennedy scale) and in the SNOT 20 questionnaire. 40 patients suffering from chronic sinusitis were divided into two equal groups: group 1: with less severe radiological changes (10 or less points on the Lund-Mackay scale), group 2: with a more advanced form (> 10 points). The relationship between VD3 and the severity of the disease (clinical and nasal endoscopy) was assessed. The mean VD3 level in patients in group 2 before surgery was lower (23.01 ng/mL) than in group 1 (28.02 ng/mL) (p < 0.05). They presented a higher degree of advanced changes in all the above scales, i.e., before the SNOT 20 procedure, the mean was: group 1: 30.33, group 2: 31.80 (p < NS) Lund-Kennedy: group 1: 3.21, group 2: 6.30 (p < 0.05). After surgery an increase in VD3 levels was observed in both study groups: in group 1 to the value of 37.98 ng/mL (p < 0.002) and in group 2 to 27.67 ng/mL (p < 0.004). Lower VD3 levels were found in patients with a higher stage of the disease. Reduction of inflammation increases the level of VD3 and reduces subjective and objective symptoms of chronic inflammation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4024c2d909bd712a2961065501bb6c0 https://pubmed.ncbi.nlm.nih.gov/34198970 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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