Therapeutic effects of one-year alendronate treatment in three cases of osteoporosis with parietal thinning of skull
| Autor: | Natsuo Yasui, Fumio Hayashi, Shinjiro Takata, Shoichiro Takao, Shusaku Yoshida |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Time Factors Urinary system Radiography Osteoporosis Urology Lumbar vertebrae Technetium Tc 99m Medronate General Biochemistry Genetics and Molecular Biology Parietal Bone parietal thinning Bone Density medicine Humans bone mineral metabolism Radionuclide Imaging Femoral neck Aged Bone mineral medicine.diagnostic_test Bone Density Conservation Agents business.industry General Medicine alendronate medicine.disease osteoporosis Surgery Skull medicine.anatomical_structure Bone scintigraphy Female Radiopharmaceuticals business bone mineral density |
| Zdroj: | The journal of medical investigation : JMI. 55(3-4):297-302 |
| ISSN: | 1343-1420 |
| Popis: | We studied the therapeutic effects of one-year alendronate treatment in three cases (two males and one female) of osteoporosis with parietal thinning of skull. Plain radiography and three dimensional computed tomography revealed asymmetric external thinning of the posteromedial part of the bilateral parietal bones. Technetium-99m methylenediphosphate bone scintigraphy did not show any changes in these three cases. Pretreatment levels of urinary type I collagen cross-linked N-telopeptides (NTX) in all three cases were high compared to the normal range. Pretreatment levels of serum bone-specific alkaline phosphatase (BAP) in the two male patients were high in contrast to the normal values in the female patient. Pretreatment mean bone mineral density (BMD) values of the 2nd to 4th lumbar vertebrae (L2-4BMD), head BMD, femoral neck BMD, and whole body BMD of all three patients were low compared with the respective normal ranges. One-year alendronate treatment decreased both urinary NTX and serum BAP in all three cases to normal values. Treatment also increased the whole body BMD in all three cases, the L2-4BMD of the female patient, the femoral neck BMD of the female patient and one male patient, and the head BMD of the female patient when compared to pretreatment levels. |
| Databáze: | OpenAIRE |
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