In vivo chemosensitivity testing in patients with gynecologic malignancies and nude mouse xenografts by monitoring cell kinetic parameters and DNA distribution patterns: a preliminary report
| Autor: | Shirley E. Greening, Bernd Uwe Sevin, Reinaldo Ramos, Hervy E. Averette, Deborah Evans, Alan Pollack |
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| Rok vydání: | 1986 |
| Předmět: |
Pathology
medicine.medical_specialty Genital Neoplasms Female medicine.medical_treatment Biopsy Cystadenoma Mice Nude Antineoplastic Agents Adenocarcinoma Flow cytometry Mice Nude mouse In vivo medicine Animals In patient Dna distribution Ovarian Neoplasms Chemotherapy medicine.diagnostic_test biology business.industry Cell Cycle Obstetrics and Gynecology DNA Neoplasm biology.organism_classification Flow Cytometry Fine-needle aspiration Oncology Female Cisplatin business Chemosensitivity assay Neoplasm Transplantation |
| Zdroj: | Gynecologic oncology. 24(1) |
| ISSN: | 0090-8258 |
| Popis: | Using flow cytometry (FCM) and autoradiography we have evaluated changes in DNA-ploidy patterns as well as cell-cycle perturbations after chemotherapy in 12 patients with accessible tumors and 22 nude mice xenografts. Gynecologic malignancies growing as nude mouse xenografts serve as an experimental model to study the effect of chemotherapy at the cellular level. Excellent correlation was found between fine needle aspiration (FNA) and biopsy material for either FCM or autoradiography. It now appears possible to study the effects of chemotherapy in the patient as well as the animal model using serial FNAs as a microsampling technique. |
| Databáze: | OpenAIRE |
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