Emerging roles of ATRX in cancer
| Autor: | L. Ashley Watson, Nathalie G. Bérubé, Hannah E. Goldberg |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Genome instability
X-linked Nuclear Protein Cancer Research Heterochromatin Biology Genomic Instability Death-associated protein 6 Telomere Homeostasis Neoplasms Genetics Animals Humans Gene Silencing Epigenetics ATRX Adaptor Proteins Signal Transducing DNA Helicases Nuclear Proteins Chromatin Assembly and Disassembly Chromatin Telomere G-Quadruplexes Gene Expression Regulation Neoplastic Cell Transformation Neoplastic Multiprotein Complexes Mutation Co-Repressor Proteins Molecular Chaperones Protein Binding |
| Zdroj: | Epigenomics. 7:1365-1378 |
| ISSN: | 1750-192X 1750-1911 |
| DOI: | 10.2217/epi.15.82 |
| Popis: | ATRX was identified over 20 years ago as the gene responsible for a rare developmental disorder characterized by α-thalassemia and intellectual disability. Similarities to the sucrose nonfermentable SNF2 type chromatin remodelers initially suggested a role in transcriptional regulation. However, over the last years, our knowledge of the epigenetic activities of ATRX has expanded steadily. Recent exciting discoveries have propelled ATRX into the limelight of chromatin and telomere biology, development and cancer research. This review summarizes recent breakthroughs in understanding ATRX function in heterochromatin structure, genome stability and its frequent dysregulation in a variety of cancers. |
| Databáze: | OpenAIRE |
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