Thyroxine metabolism in the dog
| Autor: | Charles F. Reid, David V. Becker, Eugene D. Furth, Eladio A. Nunez |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
medicine.medical_specialty
Chromatography Paper Urinary system Urine Body weight Feces Thyroxine-Binding Proteins Endocrinology Qualitative analysis Dogs Internal medicine Iodine Isotopes medicine Animals Bile Humans Physiology Comparative Chemistry Metabolism Blood Protein Electrophoresis Blood proteins Rats Thyroxine Liver Intravenous infusion procedures Autoradiography Protein Binding |
| Zdroj: | Endocrinology. 82(5) |
| ISSN: | 0013-7227 |
| Popis: | Thyroxine (T4) metabolism in the dog was evaluated by quantitative and qualitative analysis of serum, urine, fecal and bile radioactivity following the intravenous administration of radioactive T4. In addition, T4 binding by serum proteins was also studied. Proteinbound serum radioactivity decreased in a multiexponential fashion with an average half-time of disappearance of 0.43 and 5.6 days for the slower second and third components. Urinary and fecal radioactivity accumulated at similar rates to plasma disappearance with 40% of the dose in the feces and 41 % in urine by 48 hr. Fecal radioactivity was primarily T4 and urinary radioactivity iodide. A variety of T4 metabolites were found in the bile, and biliary “clearance” averaged 0.58 cc/min, considerably less than rat and greater than man when expressed in terms of body weight. Four T4 binding proteins were identified in dog serum with binding characteristics distinctly different from man. These data suggest that thyroxine metabolism in the dog differs... |
| Databáze: | OpenAIRE |
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