Preparation and Evaluation of Contact Lenses Embedded with Polycaprolactone-Based Nanoparticles for Ocular Drug Delivery
| Autor: | Abbas Shafiee, Sirous Sadeghian Chaleshtori, Farzaneh Hashemi Nasr, Mohammad Mehdi Dehghan, Sepideh Khoee |
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| Rok vydání: | 2016 |
| Předmět: |
Polymers and Plastics
Cell Survival Contact Lenses Surface Properties Polyesters Drug Evaluation Preclinical Nanoparticle Bioengineering 02 engineering and technology 010402 general chemistry Methacrylate 01 natural sciences Permeability Polyethylene Glycols Biomaterials chemistry.chemical_compound Materials Testing Polymer chemistry Materials Chemistry Animals Particle Size Cells Cultured Drug Carriers Loteprednol Etabonate Epithelium Corneal technology industry and agriculture Epithelial Cells Hydrogels 021001 nanoscience & nanotechnology 0104 chemical sciences Oxygen Contact lens Miniemulsion chemistry Chemical engineering Polycaprolactone Drug delivery Self-healing hydrogels Methacrylates Nanoparticles Female Rabbits 0210 nano-technology Drug carrier |
| Zdroj: | Biomacromolecules. 17:485-495 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/acs.biomac.5b01387 |
| Popis: | To improve the efficiency of topical ocular drug administration, we focused on development of a nanoparticles loaded contact lens to deliver the hydrophobic drug over a prolonged period of time. The cross-linked nanoparticles based on PCL (poly ε-caprolactone), 2-hydroxy ethyl methacrylate (HEMA), and poly ethylene glycol diacrylate (PEG-DA) were prepared by surfactant-free miniemulsion polymerization. The lens material was prepared through photopolymerization of HEMA and N-vinylpyrrolidone (NVP) using PEG-DA as the cross-linker. Effects of nanoparticles loading on critical contact lens properties such as transparency, water content, modulus and ion and oxygen permeabilities were studied. Nanoparticles and hydrogel showed high viability, indicating the absence of cytotoxicity and stimulatory effect. Drug release studies revealed that the hydrogel embedded with nanoparticles released the drug for a period of 12 days. The results of this study provide evidence that nanoparticles loaded hydrogels could be used for extended delivery of loteprednol etabonate and perhaps other drugs. |
| Databáze: | OpenAIRE |
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