Preclinical In Vitro Activity of QR-435 Against Influenza A Virus as a Virucide and in Paper Masks for Prevention of Viral Transmission
| Autor: | Robert Lambkin, Mario Guralnik, Carolyn LeFante, Michael P Petteruti, Richard A Rosenbloom, Kelly Digian, John S. Oxford |
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| Rok vydání: | 2007 |
| Předmět: |
Paper
Drug media_common.quotation_subject Drug Evaluation Preclinical Viral transmission Green tea extract Kidney medicine.disease_cause Antiviral Agents Virus Microbiology Dogs Virucide Influenza Human Toxicity Tests Pandemic Influenza A virus Animals Humans Medicine Pharmacology (medical) media_common Pharmacology Infection Control Dose-Response Relationship Drug Tea Plant Extracts business.industry Influenza A Virus H3N2 Subtype Masks General Medicine Combined Modality Therapy Virology In vitro business |
| Zdroj: | American Journal of Therapeutics. 14:455-461 |
| ISSN: | 1075-2765 |
| DOI: | 10.1097/mjt.0b013e3180a6f9c2 |
| Popis: | Prophylaxis against influenza is difficult, and current approaches against pandemics may be ineffective because of shortages of the two proven classes of antivirals in the face of a large-scale infection. Herbal/natural products may represent an effective alternative to conventional attempts to protect against infection by avian influenza virus. QR-435, an all-natural compound of green tea extract and other agents, has been developed to provide protection against a wide range of viral infections. The antiviral activities of several QR-435 preparations as well as QR-435 (1) green tea extract were tested against A/Sydney/5/97 and A/Panama-Resvir 17 strains of avian influenza virus H3N2 by means of an assay based on Madin-Darby canine kidney cells. Toxic effects of QR-435 formulations on these cells were also evaluated as were the virucidal properties of a commercially available mask impregnated with QR-435. The efficacy of a QR-435/mask combination was compared with that of the QR control/mask combination, an untreated mask, and no mask. QR-435 had significant in vitro activity against H3N2 at concentrations that were not associated with significant cellular toxic effects. The antiviral activity of QR-435 (1) was similar to that of QR-435. Masks impregnated with QR-435 were highly effective in blocking the passage of live H3N2 virus. These preclinical results warrant further evaluation of the prophylactic use of QR-435 against viral infection in humans. |
| Databáze: | OpenAIRE |
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