Efficacy and tolerability of short-term duloxetine treatment in adults with generalized anxiety disorder: A meta-analysis
Autor: | Chenglin Wang, Jing Liu, Heqian Du, Lijun Zhu, Shaokuan Fang, Xinyuan Li, Chunkui Zhou |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Emotions
lcsh:Medicine Social Sciences Publication Ethics Anxiety Hospital Anxiety and Depression Scale Pathology and Laboratory Medicine chemistry.chemical_compound Database and Informatics Methods 0302 clinical medicine Mathematical and Statistical Techniques Medicine and Health Sciences Psychology Database Searching lcsh:Science Research Integrity Randomized Controlled Trials as Topic Multidisciplinary Nausea Anxiety Disorders Antidepressive Agents Somatic anxiety Treatment Outcome Tolerability Research Design Physical Sciences medicine.symptom Statistics (Mathematics) Research Article Adult medicine.medical_specialty Generalized anxiety disorder Clinical Research Design Science Policy Neuropsychiatric Disorders Duloxetine Hydrochloride Placebo Research and Analysis Methods Neuroses Drug Administration Schedule Beverages 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Internal medicine Mental Health and Psychiatry medicine Duloxetine Humans Statistical Methods Nutrition Tea business.industry lcsh:R Biology and Life Sciences medicine.disease 030227 psychiatry Diet chemistry lcsh:Q Adverse Events business 030217 neurology & neurosurgery Mathematics Meta-Analysis |
Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 3, p e0194501 (2018) |
ISSN: | 1932-6203 |
Popis: | Objective To investigate the efficacy and tolerability of duloxetine during short-term treatment in adults with generalized anxiety disorder (GAD). Methods We conducted a comprehensive literature review of the PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and ClinicalTrials databases for randomized controlled trials(RCTs) comparing duloxetine or duloxetine plus other antipsychotics with placebo for the treatment of GAD in adults. Outcome measures were (1) efficacy, assessed by the Hospital Anxiety and Depression Scale(HADS) anxiety subscale score, the Hamilton Rating Scale for Anxiety(HAM-A) psychic and somatic anxiety factor scores, and response and remission rates based on total scores of HAM-A; (2) tolerability, assessed by discontinuation rate due to adverse events, the incidence of treatment emergent adverse events(TEAEs) and serious adverse events(SAEs). Review Manager 5.3 and Stata Version 12.0 software were used for all statistical analyses. Results The meta-analysis included 8 RCTs. Mean changes in the HADS anxiety subscale score [mean difference(MD) = 2.32, 95% confidence interval(CI) 1.77–2.88, P |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |