Efficacy and tolerability of short-term duloxetine treatment in adults with generalized anxiety disorder: A meta-analysis

Autor: Chenglin Wang, Jing Liu, Heqian Du, Lijun Zhu, Shaokuan Fang, Xinyuan Li, Chunkui Zhou
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Emotions
lcsh:Medicine
Social Sciences
Publication Ethics
Anxiety
Hospital Anxiety and Depression Scale
Pathology and Laboratory Medicine
chemistry.chemical_compound
Database and Informatics Methods
0302 clinical medicine
Mathematical and Statistical Techniques
Medicine and Health Sciences
Psychology
Database Searching
lcsh:Science
Research Integrity
Randomized Controlled Trials as Topic
Multidisciplinary
Nausea
Anxiety Disorders
Antidepressive Agents
Somatic anxiety
Treatment Outcome
Tolerability
Research Design
Physical Sciences
medicine.symptom
Statistics (Mathematics)
Research Article
Adult
medicine.medical_specialty
Generalized anxiety disorder
Clinical Research Design
Science Policy
Neuropsychiatric Disorders
Duloxetine Hydrochloride
Placebo
Research and Analysis Methods
Neuroses
Drug Administration Schedule
Beverages
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
Mental Health and Psychiatry
medicine
Duloxetine
Humans
Statistical Methods
Nutrition
Tea
business.industry
lcsh:R
Biology and Life Sciences
medicine.disease
030227 psychiatry
Diet
chemistry
lcsh:Q
Adverse Events
business
030217 neurology & neurosurgery
Mathematics
Meta-Analysis
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 3, p e0194501 (2018)
ISSN: 1932-6203
Popis: Objective To investigate the efficacy and tolerability of duloxetine during short-term treatment in adults with generalized anxiety disorder (GAD). Methods We conducted a comprehensive literature review of the PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and ClinicalTrials databases for randomized controlled trials(RCTs) comparing duloxetine or duloxetine plus other antipsychotics with placebo for the treatment of GAD in adults. Outcome measures were (1) efficacy, assessed by the Hospital Anxiety and Depression Scale(HADS) anxiety subscale score, the Hamilton Rating Scale for Anxiety(HAM-A) psychic and somatic anxiety factor scores, and response and remission rates based on total scores of HAM-A; (2) tolerability, assessed by discontinuation rate due to adverse events, the incidence of treatment emergent adverse events(TEAEs) and serious adverse events(SAEs). Review Manager 5.3 and Stata Version 12.0 software were used for all statistical analyses. Results The meta-analysis included 8 RCTs. Mean changes in the HADS anxiety subscale score [mean difference(MD) = 2.32, 95% confidence interval(CI) 1.77–2.88, P
Databáze: OpenAIRE
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