Anthropometric indices, lipid profile, and lipopolysaccharide-binding protein levels in metabolic endotoxemia: A case-control study in Calabar Metropolis, Nigeria
| Autor: | Edmund Richard Egbe, Bassey K Offor, Andeshongkwe Dauda, Ekong Raymond Eworo, Bassey Ikoedem Uduak, Zibril A Okhormhe |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
metabolic endotoxemia
gut microbiota lipopolysaccharide-binding protein body mass index lipid profile anthropometric indices medicine.medical_specialty Very low-density lipoprotein Waist medicine.diagnostic_test business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid lcsh:RC86-88.9 General Medicine Overweight medicine.disease chemistry.chemical_compound Endocrinology High-density lipoprotein chemistry Internal medicine Low-density lipoprotein medicine lipids (amino acids peptides and proteins) medicine.symptom Lipid profile business Body mass index Dyslipidemia |
| Zdroj: | Journal of Acute Disease, Vol 9, Iss 2, Pp 67-72 (2020) |
| ISSN: | 2221-6189 |
| DOI: | 10.4103/2221-6189.281320 |
| Popis: | Objectives: To determine the anthropometric indices, lipopolysaccharide-binding proteins (LBP), and lipid profile in patients with metabolic endotoxemia. Methods: The study comprised of 47 patients with metabolic endotoxemia (the metabolic endotoxemia group) and 43 controls (the control group). Patients in the metabolic endotoxemia group were categorized further into three subgroups including the normal weight group (n=8), the overweight group (n=12) and the obese group (n=27). Height, weight, waist, and hip circumference were measured, and waist-hip ratio (WHR) and body mass index (BMI) were calculated. LBP was determined by ELISA and total cholesterol, triglycerides, high density lipoprotein by the respective enzymatic colorimetric methods. In addition, low density lipoprotein and very low density lipoprotein were determined by Friedewald’s formula. Results: The mean waist circumference (WC), hip circumference (HC), BMI, total cholesterol, low density lipoprotein, and LBP of the metabolic endotoxemia group were significantly higher (P< 0.05) than those of the control group. WHR, TG, high density lipoprotein and very low density lipoprotein of the metabolic endotoxemia group were not significantly different (P>0.05) from those of the control group. The mean WC, HC, WHR, and BMI of the obese group with metabolic endotoxemia were significantly higher (P< 0.05) than those of the overweight group and the normal weight group with metabolic endotoxemia. Significant positive correlations were obtained between BMI and LBP (r=0.610, P=0.001), total cholesterol and LBP (r=0.385, P=0.007), TG and LBP (r=0.356, P=0.014) in patients with metabolic endotoxemia. Conclusions: Metabolic endotoxemia arising from increased circulating level of bacterial derive particles consequent to perturbation in the gut microbial community and the elevated serum level of LBP may precede the development of obesity, characterized by dyslipidemia, dysregulation of gut energy harvest, and metabolic energy imbalance. |
| Databáze: | OpenAIRE |
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