Synthesis and Antiviral Screening of Some Thieno[2,3-d]Pyrimidine Nucleosides

Autor:	Prof. Dr. Mamdouh Moawad Ali, Aymn Rashad, Mohamed Ali
Rok vydání:	2006
Předmět:	Pyrimidine Cell Survival Stereochemistry viruses Drug Evaluation Preclinical Ether Herpesvirus 1 Human Crystallography X-Ray medicine.disease_cause Antiviral Agents Biochemistry Virus Cell Line chemistry.chemical_compound Bromide Chlorocebus aethiops Genetics medicine Animals Humans Organic chemistry Antiviral screening Cell survival Molecular Structure General Medicine Pyrimidine Nucleosides Hepatitis a virus Pyrimidines Herpes simplex virus chemistry Molecular Medicine Hepatitis A virus
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 25:17-28
ISSN:	1532-2335 1525-7770
DOI:	10.1080/15257770500377730
Popis:	Some cyclic and acyclic nucleosides of thieno[2,3-d]-pyrimidine derivatives were synthesized via the reaction of compounds 1 and 2 or 3 and 4 with 2-chloroethyl methyl ether or 2,3,4, 6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide. Nucleosides 9, 10, 15, and 16 were tested as antiviral agents against herpes simplex virus type-1 (HSV-1) and hepatitis-A virus (HAV). Compound 15 showed the highest effect on HSV-1 than the other three compounds, while the four tested compounds did not show any activity against HAV.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f83aedeb3a855df895e2fcbb22be1f https://doi.org/10.1080/15257770500377730 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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