Herpetic stromal disease: Response to acyclovir/steroid therapy
| Autor: | Adeline P. Segundo, Jerry L. Taylor, Eric M. Dorn, William J. O'Brien, Julie Guy |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Stromal cell genetic structures Disease Response medicine.drug_class Corneal Stroma Prednisolone viruses Acyclovir Herpesvirus 1 Human Disease medicine.disease_cause Antiviral Agents Polymerase Chain Reaction Gastroenterology Virus Random Allocation Recurrence Internal medicine medicine Animals Glucocorticoids business.industry eye diseases Virus Shedding Ophthalmology Steroid therapy Herpes simplex virus Trigeminal Ganglion Cell culture DNA Viral Immunology Keratitis Herpetic Corticosteroid Drug Therapy Combination Virus Activation Rabbits sense organs Ophthalmic Solutions business |
| Zdroj: | Acta Ophthalmologica Scandinavica. 74:265-270 |
| ISSN: | 1395-3907 |
| DOI: | 10.1111/j.1600-0420.1996.tb00089.x |
| Popis: | The efficacy of combined acyclovir and steroid therapy in the treatment of herpetic stromal disease was evaluated by clinical evaluation of disease, the rebound of disease following termination of therapy, and the recovery of virus and viral DNA from corneas in a rabbit model. Therapy with acyclovir alone produced a significant reduction in corneal thickness in 10% of eyes. Addition of steroid to acyclovir therapy decreased the severity of stromal disease as measured by corneal thickness and increased the frequency of response to treatment to 63% of eyes. All eyes receiving acyclovir alone experienced rebound of disease following termination of therapy. Combined therapy increased the severity of rebound of corneal disease. Virus was recovered from cell cultures established after recovery from rebound in 50% of untreated and treated eyes. Viral DNA was detected by PCR in five of the nine corneal cultures which did not produce infectious virus. |
| Databáze: | OpenAIRE |
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