Pulmonary Embolism: Prospective Comparison of Iso-osmolar and Low-Osmolarity Nonionic Contrast Agents for Contrast Enhancement at CT Angiography
| Autor: | Christian Blais, Ernest Monga, Yves Patenaude, Justine P. Bédard |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Iohexol Contrast Media Double-Blind Method Triiodobenzoic Acids medicine.artery Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Aged Aged 80 and over Chi-Square Distribution medicine.diagnostic_test business.industry Respiratory disease Angiography Middle Aged Institutional review board medicine.disease Iodixanol Pulmonary embolism Clinical trial Pulmonary artery Female Radiology Pulmonary Embolism Tomography X-Ray Computed business medicine.drug |
| Zdroj: | Radiology. 234:929-933 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiol.2343031811 |
| Popis: | To prospectively evaluate contrast enhancement on pulmonary computed tomographic (CT) angiograms obtained by using an iso-osmolar versus a low-osmolarity contrast agent to exclude pulmonary embolism.Written patient consent was obtained on a form approved by the institutional review board, and the board approved the study. This prospective, randomized, double-blinded clinical trial included 47 patients referred for multi-detector row CT angiography to exclude pulmonary embolism over a 5-month period. Patients received either iohexol or iodixanol as an intravenous contrast agent. Three radiologists independently evaluated enhancement homogeneity and quality in designated pulmonary artery branches at four consecutive levels in the lower lobe of the left lung from lobar to subsegmental arteries. This evaluation was performed at a workstation separately for homogeneity and quality with two different three-level scales established with consensus. Percentages of each given score were compared with the chi2 test. The mean attenuation (expressed in Hounsfield units) for each contrast agent was compared with Student t test, and interobserver agreement (kappa value) was calculated.The percentages of arteries graded as excellent or not diagnostic were not statistically different (P.05), with comparison of the two contrast agents at all levels. The intensity of enhancement (quantitative evaluation of enhancement by using mean attenuation of vessel lumen) was similar (P.05) in the two groups. The kappa values varied from 0.35 to 0.56 among readers.Use of an iso-osmolar contrast agent at multi-detector row CT angiography to exclude pulmonary embolism did not significantly improve enhancement quality when this feature was compared with that of a low-osmolarity contrast agent. |
| Databáze: | OpenAIRE |
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