Beta-globin haplotypes from blood spots for follow-up of newborn hemoglobinopathy screening
| Autor: | Qing Xiang, Darleen R. Powars, Licheng Zeng, Fred Lorey, Alan L. Hiti |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Hemolytic anemia
Genetics Prognostic factor Disease expression Anemia business.industry Haplotype Obstetrics and Gynecology Beta globin Hematology medicine.disease Sickle cell anemia law.invention Hemoglobinopathy law hemic and lymphatic diseases Pediatrics Perinatology and Child Health Gene cluster Immunology medicine Globin business Polymerase chain reaction |
| Zdroj: | American Journal of Hematology. 54:76-78 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/(sici)1096-8652(199701)54:1<76::aid-ajh12>3.0.co;2-8 |
| Popis: | The inheritance of sickle-cell anemia upon the background of the major beta-globin gene cluster haplotypes has been associated with differing risks for major organ failure, and more recently with response to hydroxyurea treatment. Early identification of beta-globin haplotypes in individuals with sickle-cell anemia may be a clinically useful prognostic factor for severity of disease expression. This report describes the use of whole-blood spots on filter papers from newborn hemoglobinopathy screening for beta-globin gene cluster haplotyping by the polymerase chain reaction. |
| Databáze: | OpenAIRE |
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