Iris melanocytoma: Clinical features and natural course in 47 cases
| Autor: | Carol L. Shields, Arman Mashayekhi, Jerry A. Shields, Hakan Demirci, Ralph C. Eagle |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Iridectomy Intraocular pressure medicine.medical_specialty Adolescent medicine.medical_treatment Enucleation Eye Enucleation Neoplasm Seeding Anterior Eye Segment Ophthalmology medicine Humans Nevus Iris Neoplasms Iris (anatomy) Child Intraocular Pressure Aged Retrospective Studies Nevus Pigmented business.industry Retrospective cohort study Middle Aged medicine.disease Surgery medicine.anatomical_structure Child Preschool Female Melanocytoma business |
| Zdroj: | American Journal of Ophthalmology. 139:468-475 |
| ISSN: | 0002-9394 |
| Popis: | Purpose To describe the clinical features, natural course, management and histopathologic features of iris melanocytoma. Design Single-center retrospective case series. Methods patient population: Forty-seven consecutive patients (47 eyes) with iris melanocytoma. intervention procedure: Data regarding patient and tumor features were analyzed for their impact on the main outcome measures using univariate and multivariate regression models. Kaplan-Meier estimates were used to analyze the main outcomes as a function of time. main outcome measures: Increased intraocular pressure (IOP), tumor seeding, and tumor growth. Results Associated findings at initial presentation included iris stromal seeds in 20 patients (43%), and anterior chamber angle seeds in 12 (26%). Intrinsic vascularization and sector cataract were not seen in any eyes. The management at presentation included observation in 39 patients (83%), tumor removal by sector iridectomy/iridocyclectomy in 7 (15%), and enucleation for blind painful eye with secondary increased IOP in 1 (2%). The diagnosis was confirmed by histopathologic examination in 11 patients (23%). The mean follow-up was 58 months. Using Kaplan-Meier estimates, clinical evidence of growth was observed in 23% at 5 years, 48% at 10 years, and 74% at 15 years. New tumor seeds developed in 34% at 5 years, 63% at 10 years, and 75% at 15 years. Increased IOP was observed in 11% at 5 years, 11% at 10 years, and 55% at 15 years. Conclusions Iris melanocytoma represented only 3% of all iris nevi. Related iris stromal and anterior chamber angle seeds were common, and secondary glaucoma occurred in 11% at 5 years. Growth was observed in 23% at 5 years but no malignant transformation was found. |
| Databáze: | OpenAIRE |
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