Growth Differentiation Factor 15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized With COVID-19

Autor: Helge Røsjø, Christian Prebensen, Anbjørg Rangberg, Ragnhild Røysland, My Svensson, Peder L. Myhre, Signe Søvik, Jan Erik Berdal, Heidi Strand, Vibecke Sørensen, Christine M. Jonassen, Torbjørn Omland
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Oncology
Male
coronavirus
Disease
030204 cardiovascular system & hematology
medicine.disease_cause
0302 clinical medicine
cardiovascular disease
Original Research Articles
Natriuretic Peptide
Brain
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Coronavirus
risk
Middle Aged
Prognosis
Inflammatory biomarkers
Hospitalization
Intensive Care Units
C-Reactive Protein
Treatment Outcome
Area Under Curve
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Female
Cardiology and Cardiovascular Medicine
Adult
medicine.medical_specialty
Growth Differentiation Factor 15
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Sepsis
03 medical and health sciences
Troponin T
Physiology (medical)
Internal medicine
medicine
Humans
Aged
business.industry
SARS-CoV-2
biomarkers
COVID-19
medicine.disease
Peptide Fragments
ROC Curve
GDF15
business
Zdroj: Circulation
ISSN: 1524-4539
0009-7322
Popis: Supplemental Digital Content is available in the text.
Background: Growth differentiation factor 15 (GDF-15) is a strong prognostic marker in sepsis and cardiovascular disease (CVD). The prognostic value of GDF-15 in coronavirus disease 2019 (COVID-19) is unknown. Methods: Consecutive, hospitalized patients with laboratory-confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and symptoms of COVID-19 were enrolled in the prospective, observational COVID Mechanisms Study. Biobank samples were collected at baseline, day 3 and day 9. The primary end point was admission to the intensive care unit or death during hospitalization, and the prognostic performance of baseline and serial GDF-15 concentrations were compared with that of established infectious disease and cardiovascular biomarkers. Results: Of the 123 patients enrolled, 35 (28%) reached the primary end point; these patients were older, more often had diabetes, and had lower oxygen saturations and higher National Early Warning Scores on baseline. Baseline GDF-15 concentrations were elevated (>95th percentile in age-stratified healthy individuals) in 97 (79%), and higher concentrations were associated with detectable SARS-CoV-2 viremia and hypoxemia (both P
Databáze: OpenAIRE
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