Molecular signaling pathways that regulate prostate gland development
| Autor: | Gail S. Prins, Oliver Putz |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Cancer Research Context (language use) Biology Article Paracrine signalling Prostate medicine Animals Humans Hedgehog Proteins Autocrine signalling Molecular Biology Transcription factor Homeodomain Proteins Forkhead Transcription Factors Cell Biology Juxtacrine signalling Cell biology Androgen receptor medicine.anatomical_structure Immunology Androgens FOXA1 Signal Transduction Developmental Biology |
| Zdroj: | Differentiation. 76:641-659 |
| ISSN: | 0301-4681 |
| DOI: | 10.1111/j.1432-0436.2008.00277.x |
| Popis: | Prostate gland development is a complex process that involves coordination of multiple signaling pathways including endocrine, paracrine, autocrine, juxtacrine and transcription factors. To put this into proper context, the present manuscript will begin with a brief overview of the stages of prostate development and a summary of androgenic signaling in the developing prostate, which is essential for prostate formation. This will be followed by a detailed description of other transcription factors and secreted morphogens directly involved in prostate formation and branching morphogenesis. Except where otherwise indicated, results from rodent models will be presented since studies that examine molecular signaling in the developing human prostate gland are sparse at the present time. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect