Successful treatment of recurrent vulvar intraepithelial neoplasia resistant to interferon and isotretinoin with cidofovir
| Autor: | Claire F. Verschraegen, Robert Snoeck, Michel Bossens, Ralph S. Freedman, Andrzej P. Kudelka, Erik Declercq, Suphannee Koonsaeng, John J. Kavanagh, Tul Sittisomwong |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Administration Topical Injections Subcutaneous medicine.medical_treatment Organophosphonates Administration Oral Antineoplastic Agents Cervical intraepithelial neoplasia Genital warts Cytosine chemistry.chemical_compound Organophosphorus Compounds Virology medicine Humans Isotretinoin Vulvar neoplasm Chemotherapy Vulvar Neoplasms business.industry Carcinoma in situ virus diseases Uterine Cervical Dysplasia medicine.disease Vulvar intraepithelial neoplasia Drug Resistance Multiple female genital diseases and pregnancy complications Infectious Diseases chemistry Female Interferons Neoplasm Recurrence Local business Carcinoma in Situ Cidofovir medicine.drug |
| Zdroj: | Journal of Medical Virology. 64:195-198 |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | Vulvar intraepithelial neoplasias are difficult to eradicate completely without extensive surgical intervention. Cidofovir, a deoxycytidine monophosphate analog, may have a therapeutic role in this disease. A 43-year-old woman with a 20-year history of genital warts presented with extensive vulvar intraepithelial neoplasia III, and refused surgical resection. Topical cidofovir 1% in Beeler base completely eradicated the lesion. Successive treatment applications, however, were necessary. Cidofovir is a promising topical antiviral compound for HPV induced vulvar intraepithelial neoplasia. |
| Databáze: | OpenAIRE |
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