Identification of a gain-of-function STAT3 mutation (p.Y640F) in lymphocytic variant hypereosinophilic syndrome

Autor:	Richard P. Lifton, Chen Wang, Warren R. Heymann, Sarah R. Walker, Brett A. King, Bok Sil Hong, Eric C. Vonderheid, Trent Walradt, Justin R. Tanner, Stuart R. Lessin, Jonathan L. Levinsohn, Antonio Subtil, Jaehyuk Choi, Gerald Goh
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	0301 basic medicine Pathology medicine.medical_specialty Immunology Letters to Blood medicine.disease_cause Biochemistry 03 medical and health sciences hemic and lymphatic diseases medicine Eosinophilia Missense mutation STAT3 Mutation Heterogeneous group biology Hypereosinophilic syndrome business.industry Cell Biology Hematology medicine.disease 030104 developmental biology Gain of function biology.protein medicine.symptom business Target organ
Popis:	To the editor: Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by (1) persistent peripheral eosinophilia, (2) target organ pathology mediated by infiltrating eosinophils, and (3) the absence of known infectious or allergic causes of hypereosinophilia.[1][1],[2][
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e5f7d2ad8c74bcc56919817127f1a7 https://europepmc.org/articles/PMC4760095/ Zobrazit plný text záznamu