Late-acting dominant lethal genetic systems and mosquito control
| Autor: | Matthew J. Epton, Helen White-Cooper, Céline Vass, Gavin Pape, Kirsty C Condon, Hoang Kim Phuc, Guoliang Fu, Sarah Scaife, Morten H Andreasen, Luke Alphey, Christl A. Donnelly, Paul G. Coleman, Rosemary S. Burton |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Mosquito Control Time Factors Physiology Plant Science Toxicology Animals Genetically Modified Sterile insect technique 0302 clinical medicine Structural Biology Aedes lcsh:QH301-705.5 Genes Dominant Genetics 0303 health sciences education.field_of_study Agricultural and Biological Sciences(all) Pupa 3. Good health Mosquito control Larva Female General Agricultural and Biological Sciences Genetic Engineering Biotechnology Research Article Sterility 030231 tropical medicine Population Longevity Aedes aegypti Biology Models Biological General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Animals education Ecology Evolution Behavior and Systematics 030304 developmental biology Population Density Biochemistry Genetics and Molecular Biology(all) Cell Biology Tetracycline biology.organism_classification lcsh:Biology (General) Vector (epidemiology) Infertility Lethality Genes Lethal Developmental Biology |
| Zdroj: | BMC Biology BMC Biology, Vol 5, Iss 1, p 11 (2007) |
| ISSN: | 1741-7007 |
| Popis: | Background Reduction or elimination of vector populations will tend to reduce or eliminate transmission of vector-borne diseases. One potential method for environmentally-friendly, species-specific population control is the Sterile Insect Technique (SIT). SIT has not been widely used against insect disease vectors such as mosquitoes, in part because of various practical difficulties in rearing, sterilization and distribution. Additionally, vector populations with strong density-dependent effects will tend to be resistant to SIT-based control as the population-reducing effect of induced sterility will tend to be offset by reduced density-dependent mortality. Results We investigated by mathematical modeling the effect of manipulating the stage of development at which death occurs (lethal phase) in an SIT program against a density-dependence-limited insect population. We found late-acting lethality to be considerably more effective than early-acting lethality. No such strains of a vector insect have been described, so as a proof-of-principle we constructed a strain of the principal vector of the dengue and yellow fever viruses, Aedes (Stegomyia) aegypti, with the necessary properties of dominant, repressible, highly penetrant, late-acting lethality. Conclusion Conventional SIT induces early-acting (embryonic) lethality, but genetic methods potentially allow the lethal phase to be tailored to the program. For insects with strong density-dependence, we show that lethality after the density-dependent phase would be a considerable improvement over conventional methods. For density-dependent parameters estimated from field data for Aedes aegypti, the critical release ratio for population elimination is modeled to be 27% to 540% greater for early-acting rather than late-acting lethality. Our success in developing a mosquito strain with the key features that the modeling indicated were desirable demonstrates the feasibility of this approach for improved SIT for disease control. |
| Databáze: | OpenAIRE |
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