Premorbid adjustment and clinical correlates of cognitive impairment in first-episode psychosis. The PEPsCog Study
| Autor: | Àuria Albacete Belzunces, Antonio Lobo, Iluminada Corripio, Eduardo Jesús Aguilar, Rafael Penadés, ANGELA IBAÑEZ, Roberto Rodríguez-Jiménez, Miquel Bioque, Vicent Balanzá-Martínez, Anna Alonso, Ana María González-Pinto, Gisela Mezquida, Salvador Sarró, Elena De la Serna, Ana Maria Sánchez-Torres, Carla Torrent Font, Igor Bombin, Daniel Bergé, Mara Parellada, Fernando Contreras, Eva Grasa, BIBIANA CABRERA, Ana Calvo, Manuel J. Cuesta, Susana Al-Halabí, JESSICA MERCHÁN NARANJO, Julio Bobes, Miquel Bernardo, Eduard Vieta, Sara Barbeito Resa |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Adolescent medicine.medical_treatment Statistics as Topic Neuropsychological Tests behavioral disciplines and activities Young Adult mental disorders medicine Humans Affective spectrum Effects of sleep deprivation on cognitive performance Child Psychiatry Antipsychotic Cognitive impairment Biological Psychiatry Psychiatric Status Rating Scales Analysis of Variance Cognition medicine.disease Psychiatry and Mental health Psychotic Disorders Schizophrenia Female Verbal memory Cognition Disorders Psychology Clinical psychology |
| Zdroj: | Schizophrenia Research. 164:65-73 |
| ISSN: | 0920-9964 |
| Popis: | Background The extent to which socio-demographic, clinical, and premorbid adjustment variables contribute to cognitive deficits in first-episode schizophrenia spectrum disorders remains to be ascertained. Aims To examine the pattern and magnitude of cognitive impairment in first-episode psychosis patients, the profile of impairment across psychosis subtypes and the associations with premorbid adjustment. Methods 226 first-episode psychosis patients and 225 healthy controls were assessed in the PEPsCog study, as part of the PEPs study. Results Patients showed slight to moderate cognitive impairment, verbal memory being the domain most impaired compared to controls. Broad affective spectrum patients had better premorbid IQ and outperformed the schizophrenia and other psychosis groups in executive function, and had better global cognitive function than the schizophrenia group. Adolescent premorbid adjustment together with age, gender, parental socio-economic status, and mean daily antipsychotic doses were the factors that best explained patients' cognitive performance. General and adolescent premorbid adjustment, age and parental socio-economic status were the best predictors of cognitive performance in controls. Conclusions Poorer premorbid adjustment together with socio-demographic factors and higher daily antipsychotic doses were related to a generalized cognitive impairment and to a lower premorbid intellectual reserve, suggesting that neurodevelopmental impairment was present before illness onset. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect