Nanomedical detection and downstream analysis of circulating tumor cells in head and neck patients
| Autor: | Alena Gribko, Roland H. Stauber, Julian Künzel, Désirée Wünsch, Qiang Lu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Clinical Biochemistry Biochemistry 03 medical and health sciences 0302 clinical medicine Circulating tumor cell Prostate Internal medicine Humans Medicine Molecular Biology Lung business.industry Melanoma Head and neck cancer Micrometastasis Cancer Neoplastic Cells Circulating medicine.disease Head and neck squamous-cell carcinoma Nanomedicine 030104 developmental biology medicine.anatomical_structure Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell business |
| Zdroj: | Biological Chemistry. 400:1465-1479 |
| ISSN: | 1437-4315 1431-6730 |
| DOI: | 10.1515/hsz-2019-0141 |
| Popis: | The establishment of novel biomarkers in liquid biopsies of cancer patients has come more into focus in prognostic and diagnostic research efforts. Due to their prognostic relevance disseminated tumor cells or circulating tumor cells are the subject of intensive research and are discussed as early diagnostic indicators for treatment failure and the formation of micrometastases. A potential association of this early-systemic tumor component with poor prognosis of cancer patients could be already demonstrated for various entities including breast, colon, lung, melanoma, ovarian and prostate cancers. Thus, the detection of circulating tumor cells seems to be also applicable for minimal-invasive monitoring of therapy progress in head and neck cancer patients. A major problem of the use in clinical routine is that circulating tumor cells could not be detected by modern imaging techniques. To overcome these limitations highly sensitive detection methods and techniques for their molecular characterization are urgently needed allowing mechanistic understanding and targeting of circulating tumor cells. Especially the medical application of nanotechnology (nanomedical methods) has made valuable contributions to the field. Here, we want to provide a comprehensive overview on (nanomedical) detection methods for circulating tumor cells and discuss their merits, pitfalls and future perspectives especially for head and neck solid squamous cell carcinoma (HNSCC) patients. |
| Databáze: | OpenAIRE |
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