The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter
Autor: | Jun Yong Park, Young Eun Chon, Kwang Hyub Han, Kyu Sik Jung, Kyeong Hye Park, Chang Oh Kim, Kwang Joon Kim, Hye Won Lee, Ji Hye Huh, Jae Bock Chung |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Steatosis Physiology lcsh:Medicine Aminotransferases Pathology and Laboratory Medicine Biochemistry Gastroenterology Body Mass Index Diagnostic Radiology Cytopathology Fats 0302 clinical medicine Ultrasound Imaging Nonalcoholic fatty liver disease Medicine and Health Sciences Medicine lcsh:Science Tomography Univariate analysis Multidisciplinary medicine.diagnostic_test Liver Diseases Radiology and Imaging Fatty liver Middle Aged Lipids Enzymes Physiological Parameters Obesity Abdominal 030220 oncology & carcinogenesis Abdominal ultrasonography Female 030211 gastroenterology & hepatology Research Article medicine.medical_specialty Imaging Techniques Neuroimaging Gastroenterology and Hepatology Research and Analysis Methods 03 medical and health sciences Diagnostic Medicine Transferases Internal medicine Humans Obesity Aged business.industry Body Weight lcsh:R Biology and Life Sciences Proteins Odds ratio medicine.disease Computed Axial Tomography Fatty Liver Endocrinology Anatomical Pathology Enzymology lcsh:Q business Transient elastography Body mass index Neuroscience |
Zdroj: | PLoS ONE, Vol 12, Iss 10, p e0187066 (2017) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Background Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. Methods A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled. Significant steatosis was diagnosed by ultrasonography and controlled attenuation parameter (CAP) assessed by transient elastography. Results Visceral fat area (VFA) was significantly related to hepatic steatosis assessed by CAP, whereas body mass index (BMI) was related to CAP only in univariate analysis. In multiple logistic regression analysis, VFA (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.001–1.019; P = 0.028) and triglycerides (TG) (OR, 1.006; 95% CI, 1.001–1.011; P = 0.022) were independent risk factors for significant hepatic steatosis. The risk of significant hepatic steatosis was higher in patients with higher VFA: the OR was 4.838 (P200 cm2, compared to patients with a VFA ≤100 cm2. Conclusions Our data demonstrated that VFA and TG is significantly related to hepatic steatosis assessed by CAP not BMI. This finding suggests that surveillance for subjects with NAFLD should incorporate an indicator of visceral obesity, and not simply rely on BMI. |
Databáze: | OpenAIRE |
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