The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter

Autor: Jun Yong Park, Young Eun Chon, Kwang Hyub Han, Kyu Sik Jung, Kyeong Hye Park, Chang Oh Kim, Kwang Joon Kim, Hye Won Lee, Ji Hye Huh, Jae Bock Chung
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Steatosis
Physiology
lcsh:Medicine
Aminotransferases
Pathology and Laboratory Medicine
Biochemistry
Gastroenterology
Body Mass Index
Diagnostic Radiology
Cytopathology
Fats
0302 clinical medicine
Ultrasound Imaging
Nonalcoholic fatty liver disease
Medicine and Health Sciences
Medicine
lcsh:Science
Tomography
Univariate analysis
Multidisciplinary
medicine.diagnostic_test
Liver Diseases
Radiology and Imaging
Fatty liver
Middle Aged
Lipids
Enzymes
Physiological Parameters
Obesity
Abdominal
030220 oncology & carcinogenesis
Abdominal ultrasonography
Female
030211 gastroenterology & hepatology
Research Article
medicine.medical_specialty
Imaging Techniques
Neuroimaging
Gastroenterology and Hepatology
Research and Analysis Methods
03 medical and health sciences
Diagnostic Medicine
Transferases
Internal medicine
Humans
Obesity
Aged
business.industry
Body Weight
lcsh:R
Biology and Life Sciences
Proteins
Odds ratio
medicine.disease
Computed Axial Tomography
Fatty Liver
Endocrinology
Anatomical Pathology
Enzymology
lcsh:Q
business
Transient elastography
Body mass index
Neuroscience
Zdroj: PLoS ONE, Vol 12, Iss 10, p e0187066 (2017)
PLoS ONE
ISSN: 1932-6203
Popis: Background Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. Methods A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled. Significant steatosis was diagnosed by ultrasonography and controlled attenuation parameter (CAP) assessed by transient elastography. Results Visceral fat area (VFA) was significantly related to hepatic steatosis assessed by CAP, whereas body mass index (BMI) was related to CAP only in univariate analysis. In multiple logistic regression analysis, VFA (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.001–1.019; P = 0.028) and triglycerides (TG) (OR, 1.006; 95% CI, 1.001–1.011; P = 0.022) were independent risk factors for significant hepatic steatosis. The risk of significant hepatic steatosis was higher in patients with higher VFA: the OR was 4.838 (P200 cm2, compared to patients with a VFA ≤100 cm2. Conclusions Our data demonstrated that VFA and TG is significantly related to hepatic steatosis assessed by CAP not BMI. This finding suggests that surveillance for subjects with NAFLD should incorporate an indicator of visceral obesity, and not simply rely on BMI.
Databáze: OpenAIRE
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