CdS/ZnS nanocomposites: from mechanochemical synthesis to cytotoxicity issues
| Autor: | Peter Baláž, Matej Baláž, Erika Dutková, Anna Zorkovská, Jaroslav Kováč, Pavol Hronec, Mária Čaplovičová, Ján Mojžiš, Gabriela Mojžišová, Alexander Eliyas, Nina G. Kostova |
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| Rok vydání: | 2015 |
| Předmět: |
Materials science
Cell Survival Surface Properties Inorganic chemistry Nanoparticle Bioengineering 02 engineering and technology Sulfides 010402 general chemistry Spectrum Analysis Raman 01 natural sciences Nanocomposites Biomaterials chemistry.chemical_compound Cell Line Tumor Toxicity Tests Methyl orange Cadmium Compounds Humans High-resolution transmission electron microscopy Cadmium acetate Nanocomposite Aqueous solution 021001 nanoscience & nanotechnology Nanocrystalline material 0104 chemical sciences chemistry Mechanics of Materials Zinc Compounds Photocatalysis MCF-7 Cells 0210 nano-technology Nuclear chemistry |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 58 |
| ISSN: | 1873-0191 |
| Popis: | CdS/ZnS nanocomposites have been prepared by a two-step solid-state mechanochemical synthesis. CdS has been prepared from cadmium acetate and sodium sulfide precursors in the first step. The obtained cubic CdS (hawleyite, JCPDS 00-010-0454) was then mixed in the second step with the cubic ZnS (sphalerite, JCPDS 00-005-0566) synthesized mechanochemically from the analogous precursors. The crystallite sizes of the new type CdS/ZnS nanocomposite, calculated based on the XRD data, were 3-4 nm for both phases. The synthesized nanoparticles have been further characterized by high-resolution transmission electron microscopy (HRTEM) and micro-photoluminescence (μPL) spectroscopy. The PL emission peaks in the PL spectra are attributed to the recombination of holes/electrons in the nanocomposites occurring in depth associated with Cd, Zn vacancies and S interstitials. Their photocatalytic activity was also measured. In the photocatalytic activity tests to decolorize Methyl Orange dye aqueous solution, the process is faster and its effectivity is higher when using CdS/ZnS nanocomposite, compared to single phase CdS. Very low cytotoxic activity (high viability) of the cancer cell lines (selected as models of living cells) has been evidenced for CdS/ZnS in comparison with CdS alone. This fact is in a close relationship with Cd(II) ions dissolution tested in a physiological solution. The concentration of cadmium dissolved from CdS/ZnS nanocomposites with variable Cd:Zn ratio was 2.5-5.0 μg.mL(-1), whereas the concentration for pure CdS was much higher - 53 μg.ml(-1). The presence of ZnS in the nanocrystalline composite strongly reduced the release of cadmium into the physiological solution, which simulated the environment in the human body. The obtained CdS/ZnS quantum dots can serve as labeling media and co-agents in future anti-cancer drugs, because of their potential in theranostic applications. |
| Databáze: | OpenAIRE |
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